{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:14:57Z","timestamp":1785500097946,"version":"3.56.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2020,11,27]]},"abstract":"<jats:p>BACKGROUND: Birth asphyxia in term neonates remains a serious condition that causes significant mortality and long-term neurodevelopmental sequelae despite hypothermia treatment. The objective of this study was to review therapeutic hypothermia practices in a large population of neonates with hypoxic-ischemic encephalopathy (HIE) across Canada and to identify determinants of adverse outcome. METHODS: Our retrospective observational cohort study examined neonates\u226536 weeks, admitted to the Canadian Neonatal Network NICUs between 2010 and 2014, diagnosed with HIE, and treated with hypothermia. Adverse outcome was defined as death and\/or brain injury. Maternal, birth, and postnatal characteristics were compared between neonates with adverse outcome and those without. The association between the variables which were significantly different (p\u200a&lt;\u200a0.05) between the two groups and adverse outcome were further tested, while adjusting for gestational age, birth weight, gender, and initial severity of encephalopathy. RESULTS: A total of 2187 neonates were admitted for HIE; 52% were treated with hypothermia and 40% developed adverse outcome. Initial severity of encephalopathy (moderate, p\u200a=\u200a0.006; severe, p\u200a&lt;\u200a0.0001), hypotension treated with inotropes (p\u200a=\u200a0.001), and renal failure (p\u200a=\u200a0.007) were significantly associated with an increased risk of death and\/or brain injury. CONCLUSIONS: In asphyxiated neonates treated with hypothermia, not only their initial severity of encephalopathy on admission, but also their cardiac and renal complications during the first days after birth were significantly associated with risk of death and\/or brain injury. Careful monitoring and cautious management of these complications is warranted.<\/jats:p>","DOI":"10.3233\/npm-190368","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T12:23:49Z","timestamp":1587126229000},"page":"449-458","source":"Crossref","is-referenced-by-count":20,"title":["Neonates with hypoxic-ischemic encephalopathy treated with hypothermia: Observations in a large Canadian population and determinants of death and\/or brain injury"],"prefix":"10.1177","volume":"13","author":[{"given":"E.H.","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Newborn Medicine, Montreal Children\u2019s Hospital, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Canadian Neonatal Network ShahPrakesh SMD, MSc(Director, Canadian Neonatal Network and site investigator)Mount Sinai Hospital, Toronto, Ontario KanungoJaideepMDVictoria General Hospital, Victoria, British Columbia TingJosephMD B.C. Women\u2019s Hospital and Health Centre, Vancouver, British Columbia CieslakZenonMDRoyal Columbian Hospital, New Westminster, British Columbia SherlockRebeccaMDSurrey Memorial Hospital, Surrey, British Columbia YeeWendyMDFoothills Medical Centre, Calgary, Alberta ToyeJenniferMDRoyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Claveau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Newborn Medicine, Montreal Children\u2019s Hospital, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.W.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.J.","family":"Barrington","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonate Medicine, University of Montreal, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Wintermark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Newborn Medicine, Montreal Children\u2019s Hospital, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/NPM-190368_ref1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(05)71877-8","article-title":"WHO Child Health Epidemiology Reference Group. 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