{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:26:50Z","timestamp":1791289610347,"version":"4.3.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2020,11,27]]},"abstract":"<jats:p>BACKGROUND: Transient tachypnea of the newborn(TTNB) is the most common respiratory morbidity in late preterm and term babies and is pathophysiologically related to delayed lung fluid clearance after birth. Mimicking low physiological fluid intake in the initial period of life may accelerate the recovery from TTNB. In a randomized controlled trial, we compared the roles of restricted versus standard fluid management in babies with TTNB requiring respiratory support. METHODS: This parallel group,non-blinded, stratified randomized controlled trial was conducted in a level III neonatal unit of eastern India. Late preterm and term babies with TTNB requiring continuous positive airway pressure (CPAP) were randomly allocated to standard and restricted fluid arms for the first 72 hours (hrs). Primary outcome was CPAP duration. RESULTS: In total, 100 babies were enrolled in this study with 50 babies in each arm. CPAP duration was significantly less in the restricted arm (48[42, 54] hrs vs 54[48,72] hrs, p\u200a=\u200a0.002). However, no difference was observed in the incidence of CPAP failure between the two arms. In the subgroup analysis, the benefit of reduced CPAP duration persisted in late preterm but not in term infants. However, the effect was not significant in the late preterm babies exposed to antenatal steroid. CONCLUSION: This trial demonstrated the safety and effectiveness of restrictive fluid strategy in reducing CPAP duration in late preterm and term babies with TTNB. Late preterm babies, especially those not exposed to antenatal steroid were the most benefitted by this strategy.<\/jats:p>","DOI":"10.3233\/npm-190400","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T11:41:14Z","timestamp":1590147674000},"page":"477-487","source":"Crossref","is-referenced-by-count":6,"title":["A randomized controlled trial of restricted versus standard fluid management in late preterm and term infants with transient tachypnea of the newborn"],"prefix":"10.1177","volume":"13","author":[{"given":"S.","family":"Sardar","sequence":"first","affiliation":[{"name":"Department of Neonatology, Institute of Post Graduate Medical Education & Research, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Institute of Post Graduate Medical Education & Research, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ananda Mohan College, University of Calcutta, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"3","key":"10.3233\/NPM-190400_ref1","doi-asserted-by":"crossref","first-page":"e577","DOI":"10.1542\/peds.2009-0314","article-title":"Impact of labor on outcomes in transient tachypnea of the newborn: Population based study","volume":"125","author":"Tutdibi","year":"2010","journal-title":"Pediatrics"},{"issue":"12","key":"10.3233\/NPM-190400_ref2","first-page":"1317","article-title":"Effects of perinatal risk factors on common neonatal respiratory morbidities beyond 36 weeks of gestation","volume":"33","author":"Badran","year":"2012","journal-title":"Saudi Med J"},{"issue":"2","key":"10.3233\/NPM-190400_ref3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1471-0528.1995.tb09060.x","article-title":"Neonatal respiratory morbidity and mode of delivery at term: influence of timing of elective caesarian section","volume":"102","author":"Morrison","year":"1995","journal-title":"Br J Obstet Gynaecol"},{"issue":"1","key":"10.3233\/NPM-190400_ref4","first-page":"155","article-title":"Risk factors for the development of respiratory distress syndrome and transient tachypnea in newborn infants","volume":"14","author":"Dani","year":"1999","journal-title":"Italian Group of Neonatal Pneumonology. 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