{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:28:03Z","timestamp":1777890483700,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2021,9,13]]},"abstract":"<jats:p>BACKGROUND: Disseminated intravascular coagulation (DIC) with Kasabach-Merrit syndrome from a large hepatic hemangioma is life-threatening. We report a case of giant hepatic hemangioma of the newborn with KMS. RESULTS: The patient was born at 37 gestational weeks and 2 days via cesarean section; weight at birth was 2952\u200ag. Congenital duodenal atresia was noted during the fetal period. DIC developed after delivery and a giant liver hemangioma was diagnosed via abdominal CT. The cause of DIC was Kasabach\u2013Merritt syndrome owing to a giant hepatic hemangioma. First, combination therapy of 2\u200amg\/kg\/day of prednisolone and 0.2\u200amg\/kg\/day of propranolol was initiated form enterostomy. However, the size of the hepatic hemangioma did not alter, as observed via image evaluation. Therefore, 0.3\u200amg\/kg\/day of everolimus was administered frorm enterostomy. Subsequently, the size of the hepatic hemangioma was assessed via image evaluation. Although it did not alter, blood flow to the hepatic hemangioma decreased and thrombocytopenia was also suppressed. We performed hepatic lateral segmentectomy, radical operation for duodenal atresia. The pathological diagnosis of the removed tumor was infantile hemangioma. CONCLUSION: We report everolimus may be useful when PSL and propranolol are ineffective.<\/jats:p>","DOI":"10.3233\/npm-200504","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:05:16Z","timestamp":1607472316000},"page":"437-440","source":"Crossref","is-referenced-by-count":2,"title":["A case of neonate effectively treated with everolimus for giant hepatic hemangioma complicated with congenital duodenal atresia and Kasabach\u2013Merritt syndrome"],"prefix":"10.1177","volume":"14","author":[{"given":"S.","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Fujita Health University Hospital, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fujita Health University Hospital, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fujita Health University Hospital, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Naoe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Fujita Health University Hospital, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Fujita Health University Hospital, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"1","key":"10.3233\/NPM-200504_ref1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpedsurg.2011.10.037","article-title":"Lessons from a liver hemangioma registry: Subtype classification","volume":"47","author":"Kulungowski","year":"2012","journal-title":"J Pediatr Surg"},{"issue":"42","key":"10.3233\/NPM-200504_ref2","doi-asserted-by":"crossref","first-page":"12863","DOI":"10.1097\/MD.0000000000012863","article-title":"Neonatal giant hepatic hemangioma: A case report","volume":"97","author":"Zhenwei","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"10.3233\/NPM-200504_ref3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/pde.13219","article-title":"Diffuse hepatic hemangiomas successfully treated using sirolimus and high-dose propranolol","volume":"34","author":"Warren","year":"2017","journal-title":"Pediatr Dermatol"},{"issue":"9","key":"10.3233\/NPM-200504_ref4","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/ped.13630","article-title":"Efficacy of sirolimus in an infant with Kasabach-Merritt phenomenon","volume":"60","author":"Kumagai","year":"2018","journal-title":"Pediatr Int"},{"issue":"3","key":"10.3233\/NPM-200504_ref5","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/pbc.25241","article-title":"Successful treatment of Kaposiform hemangioendothelioma with everolimus","volume":"62","author":"Uno","year":"2015","journal-title":"Pediatr Blood Cancer"},{"issue":"5","key":"10.3233\/NPM-200504_ref6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1517\/14740338.2010.511611","article-title":"Everolimus: Efficacy and safety in cardiac transplantation","volume":"9","author":"Schaffer","year":"2010","journal-title":"Expert Opin Drug Saf"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NPM-200504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:38:43Z","timestamp":1777613923000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/NPM-200504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":6,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/npm-200504","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]}}}