{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:28:24Z","timestamp":1790260104136,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2021,9,13]]},"abstract":"<jats:p>BACKGROUND: Neonatal hyperbilirubinemia is a common medical emergency in early neonatal period. Unconjugated bilirubin is neurotoxic and can lead to lifelong neurological sequelae in survivors. OBJECTIVE: To find out the association between serum bilirubin and neurodevelopmental outcome at 1 year of age using Development Assessment Scale for Indian Infants (DASII). METHODS: A prospective cohort study was conducted in the Department of Pediatrics of a tertiary care institution of Central India between January 2018 and August 2019. Total 108 term healthy neonates, with at least one serum bilirubin value of &gt;15\u200amg\/dl, were included. Subjects were divided into three groups based on the serum bilirubin; group 1: (15\u201320\u200amg\/dl) \u201385(78.7%) cases, group 2: (20\u201325\u200amg\/dl) \u201317(15.7%), and group 3: (&gt;25\u200amg\/dl) \u20136(5.5%). Developmental assessment was done using DASII at 3, 6, 9, 12 months of age. RESULTS: Out of 108 cases, 101(93.5%) received phototherapy, and 7(6.5%) received double volume exchange transfusion. Severe delay was observed in 5(4.6%) and mild delay in 2(1.9%) cases in the motor domain of DASII at one year. Severe delay in the motor domain was associated with mean TSB of 27.940\u00b12.89\u200amg\/dl and mild delay with mean TSB of 22.75\u00b11.76\u200amg\/dl (p\u200a=\u200a0.001). On cluster analysis, delay was observed in locomotion 1 score in 11(13%) cases (p\u200a=\u200a0.003) and manipulation score in 6(7.1%) cases in group 1. CONCLUSION: Increased serum bilirubin was a significant risk factor for the delayed neurodevelopment in babies with neonatal jaundice. Even a moderate level of bilirubin significantly affects the developmental outcome.<\/jats:p>","DOI":"10.3233\/npm-200511","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T10:27:42Z","timestamp":1608287262000},"page":"339-344","source":"Crossref","is-referenced-by-count":8,"title":["Neurodevelopmental outcome of healthy term newborn with serum bilirubin &gt;15\u200amg\/dl at one year"],"prefix":"10.1177","volume":"14","author":[{"given":"P.","family":"Dubey","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gandhi Medical College & Kamla Nehru Hospital, Bhopal, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gandhi Medical College & Kamla Nehru Hospital, Bhopal, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.P.","family":"Choubey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gandhi Medical College & Kamla Nehru Hospital, Bhopal, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gandhi Medical College & Kamla Nehru Hospital, Bhopal, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gandhi Medical College & Kamla Nehru Hospital, Bhopal, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/NPM-200511_ref1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/pr.2013.208","article-title":"Neonatal hyperbilirubinemia and Rhesus disease of the newborn: Incidence and impairment estimates for 2010 at regional and global levels","volume":"1","author":"Bhutani","year":"2013","journal-title":"Pediatr Res"},{"issue":"4 Pt 1","key":"10.3233\/NPM-200511_ref2","first-page":"558","article-title":"American Academy of Pediatrics. Provisional Committee for Quality Improvement and Subcommittee on Hyperbilirubinemia","volume":"94","author":"Practice parameter: Management of hyperbilirubinemia in the healthy term newborn","year":"1994","journal-title":"Pediatrics"},{"key":"10.3233\/NPM-200511_ref3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2458-6-19","article-title":"Neonatal jaundice and its management: Knowledge, attitude and practice of community health workers in Nigeria","volume":"6","author":"Ogunfowora","year":"2006","journal-title":"BMC Public Health"},{"issue":"1","key":"10.3233\/NPM-200511_ref4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","author":"American Academy of Pediatrics Subcommittee on Hyperbilirubinemia","year":"2004","journal-title":"Pediatrics"},{"key":"10.3233\/NPM-200511_ref6","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1542\/peds.110.4.e50","article-title":"Moderate hyperbilirubinemia induces a transient alteration of neonatal behavior","volume":"110","author":"Paludetto","year":"2002","journal-title":"Pediatrics"},{"key":"10.3233\/NPM-200511_ref7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1440-1754.2007.01062.x","article-title":"Prediction of severe hyperbilirubinemia using the Bilicheck transcutaneous bilirubinometer","volume":"43","author":"Boo","year":"2007","journal-title":"J Paediatr Child Health"},{"key":"10.3233\/NPM-200511_ref8","doi-asserted-by":"crossref","unstructured":"Nass RD , Frank Y . Cognitive and Behavioral Abnormalities of Pediatric Diseases. 1st ed Oxford University Press. (2010).","DOI":"10.1093\/oso\/9780195342680.001.0001"},{"key":"10.3233\/NPM-200511_ref9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s13312-018-1245-0","article-title":"Neurodevelopmental status of children aged 6-30 months with severe acute malnutrition","volume":"55","author":"Dwivedi","year":"2018","journal-title":"Indian Pediatr"},{"key":"10.3233\/NPM-200511_ref10","first-page":"7","article-title":"Bilirubin induced encephalopathy","volume":"14","author":"Karimzadeh","year":"2020","journal-title":"Iran J Child Neurol"},{"key":"10.3233\/NPM-200511_ref11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.clp.2016.01.007","article-title":"Bilirubin\u2014induced neurotoxicity in the preterm neonate","volume":"43","author":"Watchko","year":"2016","journal-title":"Clin Perinatol"},{"key":"10.3233\/NPM-200511_ref12","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S2352-4642(18)30139-1","article-title":"Neonatal hyperbilirubinaemia: A global perspective","volume":"2","author":"Olusanya","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"10.3233\/NPM-200511_ref13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/20469047.2019.1707397","article-title":"Management of neonatal jaundice in low\u2014and middle\u2014income countries","volume":"40","author":"Slusher","year":"2020","journal-title":"Paediatr Int Child Health"},{"key":"10.3233\/NPM-200511_ref14","doi-asserted-by":"crossref","first-page":"699","DOI":"10.12968\/hmed.2017.78.12.699","article-title":"Neonatal jaundice: Etiology, diagnosis and treatment","volume":"78","author":"Mitra","year":"2017","journal-title":"Br J Hosp Med (Lond)"},{"key":"10.3233\/NPM-200511_ref15","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1542\/peds.114.1.e130","article-title":"An evidence-based review of important issues concerning neonatal hyperbilirubinemia","volume":"114","author":"Ip","year":"2004","journal-title":"Pediatrics"},{"issue":"01","key":"10.3233\/NPM-200511_ref16","first-page":"18","article-title":"Assessment of neurodevelopmental abnormalities in children with severe acute malnutrition between the age of 6 months to 30 months","volume":"09","author":"Jain","year":"2018","journal-title":"Int J Biomed Res"},{"key":"10.3233\/NPM-200511_ref17","first-page":"165","article-title":"Neurological prognosis in term newborns with neonatal indirect hyperbilirubinemia","volume":"38","author":"Yilmaz","year":"2001","journal-title":"Indian Pediatrics"},{"issue":"4","key":"10.3233\/NPM-200511_ref18","first-page":"599","article-title":"Hyperbilirubinemia in the term newborn","volume":"65","author":"Porter","year":"2002","journal-title":"Am Fam Physician"},{"key":"10.3233\/NPM-200511_ref19","first-page":"93","article-title":"Predictors of abnormal neurodevelopmental at 6 months in term babies with early neonatal hyperbilirubinemia. A prospective cohort study from South India","volume":"15","author":"Babu","year":"2011","journal-title":"Curr Pediatr Res"},{"key":"10.3233\/NPM-200511_ref20","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1542\/peds.2010-0052","article-title":"Neonatal jaundice, autism, and other disorders of psychological development","volume":"126","author":"Maimburg","year":"2010","journal-title":"Pediatrics"},{"key":"10.3233\/NPM-200511_ref21","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.7717\/peerj.294","article-title":"Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates-a 30 year prospective follow-up study","volume":"2","author":"Hokkanen","year":"2014","journal-title":"Peer J"},{"key":"10.3233\/NPM-200511_ref22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1542\/peds.2007-0967","article-title":"Outcomes in a Population of healthy term and near-term infants with serum bilirubin levels of\u2265325\u03bcmol\/L (\u226519 mg\/dL) who were born in nova scotia, Canada, Between 1994 and 2000","volume":"122","author":"Jangaard","year":"2008","journal-title":"Pediatrics"},{"issue":"4","key":"10.3233\/NPM-200511_ref23","doi-asserted-by":"crossref","first-page":"e925","DOI":"10.1542\/peds.2011-0206","article-title":"Risk factors for neurotoxicity in newborns with severe neonatal hyperbilirubinemia","volume":"128","author":"Gamaleldin","year":"2011","journal-title":"Pediatrics"},{"key":"10.3233\/NPM-200511_ref24","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1056\/NEJMoa054244","article-title":"Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more","volume":"354","author":"Newman","year":"2006","journal-title":"N Engl J Med"},{"key":"10.3233\/NPM-200511_ref25","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1542\/peds.2004-1870","article-title":"Neonatal hyperbilirubinemia and risk of autism spectrum disorders","volume":"115","author":"Croen","year":"2005","journal-title":"Pediatrics"},{"key":"10.3233\/NPM-200511_ref26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1542\/peds.2011-2760","article-title":"Follow-up of neonates with total serum bilirubin levels\u226525 mg\/dL: A Danish population-based study","volume":"130","author":"Vandborg","year":"2012","journal-title":"Pediatrics"},{"key":"10.3233\/NPM-200511_ref27","doi-asserted-by":"crossref","first-page":"287e93","DOI":"10.1097\/00004703-199110000-00001","article-title":"Neonatal bilirubin exposure and psychoeducational outcome","volume":"12","author":"Hansen","year":"1991","journal-title":"J Dev Behav Pediatr"},{"issue":"3","key":"10.3233\/NPM-200511_ref28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3233\/NPM-15814111","article-title":"Predictive value of cord blood bilirubins for hyperbilirubinemia in neonates at risk for maternal-fetal blood group incompatibility and hemolytic disease of the newborn","volume":"8","author":"Calkins","year":"2015","journal-title":"J Neonatal Perinatal Med"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NPM-200511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:38:44Z","timestamp":1777613924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/NPM-200511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":27,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/npm-200511","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]}}}