{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:48:06Z","timestamp":1790700486421,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2021,11,12]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>To determine the association between plasma hemoglobin (HB) at three time-points (birth, postnatal days 0\u20133 and 0\u201310) and spontaneous closure of the ductus arteriosus (sDAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN:<\/jats:title>\n                    <jats:p>A retrospective case-control study of preterm infants born (2013\u20132016) between 24 and 29 weeks of gestational age (GA) was conducted in a level three perinatal center in Switzerland. We collected hemoglobin at birth, between days 0\u20133 and 0\u201310 in two distinct groups: (i) patients treated for a PDA and (ii) patients with spontaneous closure of the ductus arteriosus (sDAC). Antenatal and postnatal demographic data and neonatal morbidity were collected. Bivariate analysis was performed and a stepwise logistic regression was done to investigate factors associated with sDAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>We reviewed the medical chart of 184 premature infants of whom 146 (79.3%) satisfied eligibility criteria. Of these, 74 (51%) were classified as sDAC. Patients with sDAC were older (GA: 28 vs 27, p\u200a&lt;\u200a0.001), more stable (clinical risk index for babies score (CRIB score): 2 vs 5, p\u200a&lt;\u200a0.001) and had better clinical outcomes than patients who received treatment for a PDA. Infants in the sDAC group had a higher level of hemoglobin during the first ten postnatal days. Multiple logistic regression analysis revealed that lower HB level (day 0\u201310) were associated with failure of sDAC ( p\u200a&lt;\u200a0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This is one of the first studies to highlight a potential association between hemoglobin during the transitional period and sDAC. The biological nature of this observation requires prospective clarification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/npm-200518","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T12:23:55Z","timestamp":1611923035000},"page":"493-502","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of hemoglobin and spontaneous closure of the ductus arteriosus during the transitional period in very low birth weight infants"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8115-9977","authenticated-orcid":false,"given":"S.","family":"Joye","sequence":"first","affiliation":[{"name":"Clinic of Neonatology, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Stead family Children\u2019s Hospital, Iowa City, Iowa, USA"},{"name":"Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA"},{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.E.","family":"Giesinger","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Stead family Children\u2019s Hospital, Iowa City, Iowa, USA"},{"name":"Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-F.","family":"Tolsa","sequence":"additional","affiliation":[{"name":"Clinic of Neonatology, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sekarski","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1528"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3431"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-008-0017-7"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02468.x"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304695"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1995.02170230090013"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.09.001"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.05.007"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2060"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2010.06.006"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3730"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2654"},{"key":"ref013","doi-asserted-by":"crossref","unstructured":"HechtE. Physique. De Boeck Universit\u00e9. 1999:Chapitre 11, pp. 431-433.","DOI":"10.1016\/S0922-1425(99)00023-7"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1542\/neo.2-5-e110"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12199"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-019-0706-y"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.01.006"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003248.pub3"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000512.pub2"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.09.028"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-303816"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-fluid-010814-014513"},{"issue":"10","key":"ref024","first-page":"e406","volume":"5","author":"Linderkamp O","year":"2004","journal-title":"American Academy of Pediatrics"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1542\/peds.74.1.45"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-200518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/NPM-200518","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-200518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:38:45Z","timestamp":1777613925000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/NPM-200518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,11,12]]}},"alternative-id":["10.3233\/NPM-200518"],"URL":"https:\/\/doi.org\/10.3233\/npm-200518","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]}}}