{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:15:09Z","timestamp":1787728509043,"version":"build-2784847793"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:p>Renal cystic diseases are a clinically and genetically diverse group of renal diseases that can manifest in utero, infancy, or throughout childhood and adulthood. These diseases may be unilateral or bilateral with a single cyst or multiple cysts, or with increased echogenicity of the renal cortex without macroscopic cysts. Certain cystic renal diseases are life-threatening, with many developing chronic kidney and hepatic disease if not recognized early enough. Therefore, due to the prevalence and life-altering complications of this specific group of diseases in vulnerable populations, it is crucial for clinicians and healthcare providers to have an overall understanding of cystic diseases and how to pre-emptively detect and manage these conditions. In this review, we discuss in detail the epidemiology, genetics and pathophysiology, diagnosis, presentation, and management of numerous genetic and sporadic renal cystic diseases, such as polycystic kidney disease, multicystic dysplastic kidney, and calyceal diverticula, with an emphasis on prenatal care and pregnancy counseling.<\/jats:p>","DOI":"10.3233\/npm-200520","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T19:30:09Z","timestamp":1600803009000},"page":"163-176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Renal cystic diseases during the perinatal and neonatal period"],"prefix":"10.1177","volume":"14","author":[{"given":"R.","family":"Raina","sequence":"first","affiliation":[{"name":"Department of Nephrology, Akron Children\u2019s Hospital, Akron, OH, USA"},{"name":"Akron Nephrology Associates\/Cleveland Clinic Akron General, Akron, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"DeCoy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Akron Children\u2019s Hospital, Akron, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Akron Children\u2019s Hospital, Akron, OH, USA"},{"name":"Akron Nephrology Associates\/Cleveland Clinic Akron General, Akron, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Revere High School, Richfield, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Genetics, MetroHealth Medical Center\/Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, MetroHealth Medical Center\/Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, MetroHealth Medical Center\/Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Medicine, Nephrology, University Hospital Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"ref001","unstructured":"PatilA, SweeneyWE, AvnerED, PanC. Childhood Polycystic Kidney Disease. In: Li X, ed. Polycystic Kidney Disease. Codon. 2015:21-60."},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00221"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1358263"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2017.07.040"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.3938"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2011.05.001.The"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.3909\/riu0581"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2018.08.017"},{"key":"ref009","unstructured":"AvniFE. The Fetal Genitourinary Track. In: Callen P, ed. Ultrasonography in Obstetrics and Gynecology, 5th Edition. Philadelphia, PA: Saunders Elsevier; 2008."},{"key":"ref010","unstructured":"BianchiDW, CrombleholmeTM, D\u2019AltonME MF. Fetology: Diagnosis and Management of the Fetal Patient. In: Fetology: Diagnosis and Management of the Fetal Patient. 2nd ed. New York, NY: McGraw-Hill; 2010."},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07328.x"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.08.015"},{"key":"ref013","unstructured":"BraunDA, HildebrandtF. Ciliopathies. Cold Spring Harb Perspect Biol. 2017:1-28."},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-015-0541-7"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018181243"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.3520"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000985"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1578-y"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2015.04.013"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-202301"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31084"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.09.001"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96729"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.06.015"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.03.052"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010101080"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0155-2"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfy088"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907419"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12726"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-200520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/NPM-200520","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NPM-200520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:38:46Z","timestamp":1777613926000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/NPM-200520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3,16]]}},"alternative-id":["10.3233\/NPM-200520"],"URL":"https:\/\/doi.org\/10.3233\/npm-200520","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]}}}