{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:28:17Z","timestamp":1777890497113,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2021,9,13]]},"abstract":"<jats:p>Background: As neonates transition from a relatively hypoxic environment to extra-uterine life, arterial oxygen saturation dramatically increases. This transition occurs while most organs have not fully matured. The ability for immature tissue to adequately extract and utilize oxygen remains largely unknown. With the development of near-infrared spectroscopy (NIRS), measuring specific tissue oxygen saturation (StO2) noninvasively, clinicians can measure StO2 and determine if adequate tissue oxygenation is maintained. The objective of this study is to determine the relationships of NIRS brain and somatic autoregulation function to patients\u2019 severity of illness. Methods: In this prospective cohort pilot study, after parental consent, neonates less than 34 weeks with arterial access, were enrolled. The FORE-SIGHT NIRS probe was placed on the forehead and abdominal wall for 24 hours. Continuous arterial blood pressure, SpO2 and cerebral and somatic NIRS were used to derive autoregulation function. Results: Data was obtained from 17 neonates (0.540 to 2.37\u200akg, gestation 23.0 to 33.2 weeks). The autoregulation function categorizes pressure passive index (PPI) values as good, borderline, or poor. For normal autoregulation function, PPI values tend to be low and fairly constant for a range of MAP. The PPI borderline zone is a hypothetical range of PPI values where autoregulation function transitions from good to poor. Conclusion: Our results show most premature neonates, as long as they maintained normal BP and systemic circulation can autoregulate cerebral perfusion. When BP are above or below the normal MAP for age, the neonate is at risk for losing brain and somatic autoregulation.<\/jats:p>","DOI":"10.3233\/npm-200601","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T20:05:17Z","timestamp":1610481917000},"page":"345-352","source":"Crossref","is-referenced-by-count":3,"title":["Pilot study of cerebral and somatic autoregulation using NIRS in preterm neonates"],"prefix":"10.1177","volume":"14","author":[{"given":"T.M.","family":"Traub","sequence":"first","affiliation":[{"name":"Department of Neonatology, Children\u2019s National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Grabowski","sequence":"additional","affiliation":[{"name":"Biomedical engineering, Children\u2019s National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Rais-Bahrami","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children\u2019s National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/NPM-200601_ref1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/s41390-018-0141-6","article-title":"Neonatal cerebrovascular autoregulation","volume":"84","author":"Rhee","year":"2018","journal-title":"Pediatr Res"},{"key":"10.3233\/NPM-200601_ref2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1203\/PDR.0b013e31815ed64c","article-title":"Understanding the susceptibility of the premature Neonate to necrotizing enterocolitis (NEC)","volume":"63","author":"Hunter","year":"2008","journal-title":"Pediatr Res"},{"key":"10.3233\/NPM-200601_ref3","first-page":"159","article-title":"Monitoring cerebral oxygenation of the immature brain:Aneuroprotective strategy?","volume":"84","author":"Van Bel","year":"2018","journal-title":"PediatrRes"},{"key":"10.3233\/NPM-200601_ref4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1203\/pdr.0b013e31803237f6","article-title":"Fluctuating pressure-passivity is common in the cerebral circulation of sick premature neonates","volume":"61","author":"Soul","year":"2007","journal-title":"Pediatr Res"},{"key":"10.3233\/NPM-200601_ref5","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/pr.2017.196","article-title":"Gestational age-dependent relationship between cerebral oxygen extraction and blood pressure","volume":"82","author":"Vesoulis","year":"2017","journal-title":"Pediatr Res"},{"key":"10.3233\/NPM-200601_ref6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41390-019-0466-9","article-title":"Regional tissue oxygenation monitoring in the neonatal intensive care unit: evidence for clinical strategies and future directions","volume":"86","author":"Mintzer","year":"2019","journal-title":"Pediatr Res"},{"issue":"1","key":"10.3233\/NPM-200601_ref7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/jcbfm.2013.165","article-title":"Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia","volume":"34","author":"Dehaes","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.3233\/NPM-200601_ref9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-0003-1-2","article-title":"Time and frequency domain methods for quantifying common modulation of motor unit firing patterns","volume":"1","author":"Myers","year":"2004","journal-title":"J Neuroeng Rehabil"},{"key":"10.3233\/NPM-200601_ref10","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fped.2017.00276","article-title":"Significant correlation between regional tissue oxygen saturation and vital signs of critically ill infants","volume":"5","author":"Massa-Buck","year":"2017","journal-title":"Front. 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