{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:30:18Z","timestamp":1777890618049,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2022,4,12]]},"abstract":"<jats:p>BACKGROUND: Multisystem inflammatory syndrome in Children (MIS-C) is a postinfectious immune mediated hyperinflammatory state seen in children and adolescent below 21 year of age and develop after 4\u20136 weeks of severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2) infection, however, it is rare in neonates. We report an extremely rare and first of its kind case of MIS-C in a neonate with persistent neutropenia. CASE DESCRIPTION: A 19-day old boy presented with complaints of fever and loose stools for 1 day and developed rash after admission. Baby was investigated for sepsis and commenced on IV antibiotics empirically. In view of persistent fever, diarrhoea, rash and absence of obvious microbial etiology of inflammation, with elevated inflammatory marker and an epidemiologic link to SARS-CoV-2 infection, the diagnosis of MIS-C-was made. Intravenous immunoglobulin (IVIg) was administered and defervescence occurred within 24 hours. He also developed neutropenia during course of illness which persisted on follow up. CONCLUSION: MIS-C in neonates is uncommon and fever with elevated inflammatory markers during COVID-19 pandemic should alert the pediatrician to the possibility of MIS-C. Neutropenia may be associated with MIS-C in neonates and warrants prolonged follow up.<\/jats:p>","DOI":"10.3233\/npm-210839","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T14:30:25Z","timestamp":1629815425000},"page":"373-377","source":"Crossref","is-referenced-by-count":19,"title":["Multisystem inflammatory syndrome with persistent neutropenia in neonate exposed to SARS-CoV-2 virus: A case report and review of literature"],"prefix":"10.1177","volume":"15","author":[{"given":"K.","family":"Diwakar","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Tata Main Hospital, Jamshedpur, Jharkhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Tata Main Hospital, Jamshedpur, Jharkhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.W.","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Tata Main Hospital, Jamshedpur, Jharkhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Rohtak, Haryana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Jhajra","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Tata Main Hospital, Jamshedpur, Jharkhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"7","key":"10.3233\/NPM-210839_ref2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41591-020-0968-3","article-title":"Extrapulmonary manifestations of COVID-19","volume":"26","author":"Gupta","year":"2020","journal-title":"Nat Med"},{"issue":"9","key":"10.3233\/NPM-210839_ref3","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1093\/cid\/ciaa556","article-title":"SARS-CoV-2 (COVID-19): What do we know about children? A systematic review","volume":"71","author":"Mehta","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.3233\/NPM-210839_ref4","article-title":"Outcomes of neonates born to mothers with coronavirus disease 2019 (COVID-19) - National Neonatology Forum (NNF) India COVID-19 Registry","volume":"20","author":"NATIONAL NEONATOLOGY FORUM (NNF) COVID-19 REGISTRY GROUP","year":"2021","journal-title":"Indian Pediatr"},{"issue":"11","key":"10.3233\/NPM-210839_ref5","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1016\/S1473-3099(20)30651-4","article-title":"COVID-19 and multisystem inflammatory syndrome in children and adolescents","volume":"20","author":"Jiang","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"10.3233\/NPM-210839_ref6","first-page":"51","article-title":"Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation","volume":"38","author":"Radia","year":"2021","journal-title":"Paediatr Respir Rev"},{"issue":"4","key":"10.3233\/NPM-210839_ref7","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S2352-4642(21)00055-9","article-title":"Multisystem inflammatory syndrome in a neonate, temporally associated with prenatal exposure to SARS-CoV-2: A case report","volume":"5","author":"Kappanayil","year":"2021","journal-title":"Lancet Child Adolesc Health"},{"issue":"4","key":"10.3233\/NPM-210839_ref8","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.1097\/INF.0000000000003054","article-title":"COVID-19-related potential multisystem inflammatory syndrome in childhood in a neonate presenting as persistent pulmonary hypertension of the newborn","volume":"40","author":"Khaund Borkotoky","year":"2021","journal-title":"Pediatr Infect Dis J"},{"issue":"22","key":"10.3233\/NPM-210839_ref9","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1016\/j.vaccine.2021.01.054","article-title":"Multisystem inflammatory syndrome in children and adults (MIS-C\/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data","volume":"39","author":"Vogel","year":"2021","journal-title":"Vaccine"},{"issue":"12","key":"10.3233\/NPM-210839_ref10","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3390\/v12121384","article-title":"Persistent Detection and Infectious Potential of SARS-CoV-2 Virus in Clinical Specimens from COVID-19 Patients","volume":"12","author":"Zapor","year":"2020","journal-title":"Viruses"},{"issue":"8","key":"10.3233\/NPM-210839_ref11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3390\/diagnostics10080583","article-title":"Benefits and Risks of IgG Transplacental Transfer","volume":"10","author":"Ciobanu","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"10.3233\/NPM-210839_ref12","doi-asserted-by":"crossref","first-page":"100752","DOI":"10.1016\/j.nmni.2020.100752","article-title":"Clinical and immunologic features among COVID-19-affected mother-infant pairs: antibodies to SARS-CoV-2 detected in breast milk","volume":"37","author":"Gao","year":"2020","journal-title":"New Microbes New Infect"},{"issue":"8","key":"10.3233\/NPM-210839_ref13","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/annrheumdis-2020-217960","article-title":"Paediatric multisystem infammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): A multicenter cohort","volume":"79","author":"Pouletty","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.3233\/NPM-210839_ref14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1056\/NEJMoa2021680","article-title":"Multisystem inflammatory syndrome in US Children and adolescents","volume":"383","author":"Feldstein","year":"2020","journal-title":"N Engl J Med"},{"issue":"1","key":"10.3233\/NPM-210839_ref15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00296-020-04749-4","article-title":"Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: Immunological mechanisms, clinical manifestations and management","volume":"41","author":"Kabeerdoss","year":"2021","journal-title":"Rheumatol Int"},{"issue":"5","key":"10.3233\/NPM-210839_ref16","first-page":":591","article-title":"Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface","volume":"2","author":"Lu-Culligan","year":"2021","journal-title":"Med (N Y)"},{"issue":"1","key":"10.3233\/NPM-210839_ref17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00296-020-04749-4","article-title":"Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management","volume":"41","author":"Kabeerdoss","year":"2021","journal-title":"Rheumatol Int"},{"key":"10.3233\/NPM-210839_ref18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jpeds.2020.04.051","article-title":"Severe neutropenia in infants with severe acute respiratory syndrome caused by the novel coronavirus infection","volume":"222","author":"Venturini","year":"2020","journal-title":"J Pediatr"},{"issue":"5","key":"10.3233\/NPM-210839_ref19","doi-asserted-by":"crossref","first-page":"e28866","DOI":"10.1002\/pbc.28866","article-title":"Post-COVID-19 severe neutropenia","volume":"68","author":"Bouslama","year":"2021","journal-title":"Pediatr Blood Cancer"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NPM-210839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:41:58Z","timestamp":1777614118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/NPM-210839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":18,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/npm-210839","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,12]]}}}