{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:26:39Z","timestamp":1787970399486,"version":"build-2784847793"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2022,4,12]]},"abstract":"<jats:p>BACKGROUND: Hyperbilirubinemia is a common problem in neonates. The aim of this study was to evaluate the effect of synbiotic in addition to routine phototherapy on the treatment of neonatal jaundice. METHOD: This double-blind clinical trial, was performed on 194, 3\u201314 days old neonates. Neonates were divided into intervention and placebo groups. The intervention group received 5 drops of oral synbiotic daily along with phototherapy and the placebo group underwent phototherapy plus a placebo. Gestational age, age, weight, sex, initial and daily bilirubin level, frequency of defecation, mode of delivery, and length of hospitalization were assessed. RESULTS: The rate of bilirubin reduction on the first day of admission was significantly higher in the intervention group (2.9\u00b11.81 vs. 2.06\u00b11.93, p\u200a=\u200a0.002). The mean level of bilirubin on the second (9.8\u00b11.92 vs. 10.88\u00b12.26) and third days (8.06\u00b11.54 vs. 9.86\u00b11.7) was lower in the intervention group (p\u200a=\u200a0.001). The proportion of discharged patients in the third and fourth days was higher in the intervention group compared to the control (65% vs. 41%, 99% vs. 86.5%, respectively, p\u200a=\u200a0.001). However, the duration of hospitalization was shorter in the intervention group compared to the control (2.36\u00b10.5 vs. 2.74\u00b10.74, p\u200a=\u200a0.001). CONCLUSION: Based on our results, daily treatment with 5 drops of synbiotic along with phototherapy can be a safe and effective modality in faster bilirubin reduction, decreasing the hospitalization period and phototherapy. Therefore, it seems that it can be used as an adjunct therapy for neonates with jaundice.<\/jats:p>","DOI":"10.3233\/npm-210847","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T10:38:02Z","timestamp":1640342282000},"page":"327-333","source":"Crossref","is-referenced-by-count":8,"title":["Therapeutic effects of synbiotic on neonates with gestational age over 34 weeks admitted for jaundice"],"prefix":"10.1177","volume":"15","author":[{"given":"S.A.H.","family":"Nouri","sequence":"first","affiliation":[{"name":"Pediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Zabol University of Medical Sciences, Zabol, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.N.","family":"Moghaddam","sequence":"additional","affiliation":[{"name":"Pediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.H.","family":"Rad","sequence":"additional","affiliation":[{"name":"Pediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zarkesh","sequence":"additional","affiliation":[{"name":"Pediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"5","key":"10.3233\/NPM-210847_ref1","first-page":"558","article-title":"Hyperbilirubinemia in neonates: Types, causes, clinical examinations, preventive measures and treatments: A narrative review article","volume":"45","author":"Ullah","year":"2016","journal-title":"Iran J Public Health"},{"issue":"2","key":"10.3233\/NPM-210847_ref2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1542\/peds.91.2.470","article-title":"Hyperbilirubinemia in the breast-fed newborn: A controlled trial of four interventions","volume":"91","author":"Martinez","year":"1993","journal-title":"Pediatrics"},{"issue":"01","key":"10.3233\/NPM-210847_ref3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-2007-994402","article-title":"Effect of different phototherapy lights on incubator characteristics and dynamics under three modes of servocontrol","volume":"12","author":"Dollberg","year":"1995","journal-title":"Am J Perinatol"},{"issue":"07","key":"10.3233\/NPM-210847_ref4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1055\/s-2001-18698","article-title":"Transepidermal water loss and skin hydration in preterm infants during phototherapy","volume":"18","author":"Maayan-Metzger","year":"2001","journal-title":"Am J Perinatol"},{"issue":"4","key":"10.3233\/NPM-210847_ref5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1399-3038.2006.00518.x","article-title":"Is neonatal phototherapy associated with an increased risk for hospitalized childhood bronchial asthma?","volume":"18","author":"Aspberg","year":"2007","journal-title":"Pediatr Allergy Immuno"},{"issue":"18","key":"10.3233\/NPM-210847_ref6","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.3109\/14767058.2015.1113520","article-title":"Prebiotics for the management of hyperbilirubinemia in preterm neonates","volume":"29","author":"Armanian","year":"2016","journal-title":"JMatern Fetal Neonatal Med"},{"issue":"suppl_2","key":"10.3233\/NPM-210847_ref7","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1093\/cid\/cix114","article-title":"Effectiveness of probiotic, prebiotic, and synbiotic therapies in reducing postoperative complications: a systematic review and network meta-analysis","volume":"64","author":"Kasatpibal","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.3233\/NPM-210847_ref8","first-page":"1172","article-title":"Therapeutic effects of probiotics on neonatal jaundice","volume":"31","author":"Liu","year":"2015","journal-title":"Pak J Med Sci Q"},{"issue":"326","key":"10.3233\/NPM-210847_ref10","first-page":"2161","article-title":"Treatment effect of probiotic Bacillus clausii on neonatal jaundice in late preterm and term newborn babies: An experimental study","volume":"7","author":"Chandrasekhar","year":"2017","journal-title":"Pediatr Ther"},{"issue":"1","key":"10.3233\/NPM-210847_ref11","first-page":"e5096","article-title":"The effect of probiotics on reducing hospitalization duration in infants with hyperbilirubinemia","volume":"27","author":"Torkaman","year":"2017","journal-title":"Iran J Pediatr"},{"issue":"11","key":"10.3233\/NPM-210847_ref12","first-page":"12","article-title":"Role of Saccharomyces boulardii in reduction of neonatal hyperbilirubinemia","volume":"10","author":"Suganthi","year":"2016","journal-title":"J Clin Diagn: JCDR"},{"issue":"02","key":"10.3233\/NPM-210847_ref13","first-page":"137","article-title":"Effects of Saccharomyces boulardii on neonatal hyperbilirubinemia: a randomized controlled trial","volume":"32","author":"Serce","year":"2015","journal-title":"Am J Perinatol"},{"issue":"10","key":"10.3233\/NPM-210847_ref14","first-page":"5953","article-title":"Effect of probiotics on serum bilirubin level in term neonates with jaundice: A randomized clinical trial","volume":"5","author":"Zahed Pasha","year":"2017","journal-title":"Int J Pediatr"},{"issue":"1","key":"10.3233\/NPM-210847_ref15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","author":"American Academy of Pediatrics Subcommittee on Hyperbilirubinemia","year":"2004","journal-title":"Pediatrics"},{"issue":"1","key":"10.3233\/NPM-210847_ref16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1824-7288-40-62","article-title":"Progress in pediatrics in 2013: Choices in allergology, endocrinology, gastroenterology, hypertension, infectious diseases, neonatology, neurology, nutrition and respiratory tract illnesses","volume":"40","author":"Caffarelli","year":"2014","journal-title":"Ital J Pediatr"},{"issue":"7","key":"10.3233\/NPM-210847_ref17","first-page":"104","article-title":"Effect of oral probiotics on treatment of neonates with hyperbilirubinemia and its influence on immune function","volume":"19","author":"Jia","year":"2015","journal-title":"J Clin Med Pract"},{"issue":"5","key":"10.3233\/NPM-210847_ref18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.5223\/pghn.2019.22.5.453","article-title":"Effect of synbiotic on the treatment of jaundice in full term neonates: A randomized clinical trial","volume":"22","author":"Ahmadipour","year":"2019","journal-title":"Pediatr Gastroenterol Hepatol Nutr"},{"key":"10.3233\/NPM-210847_ref19","first-page":"479","article-title":"A clinical observation on effect of \u201cmamiai\u201d on lowering breast milk jaundice by quickly constructing intestinal microflora","volume":"4","author":"Ling-ling","year":"2006","journal-title":"Clin J Med Officer"},{"issue":"10","key":"10.3233\/NPM-210847_ref20","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1111\/j.1651-2227.2009.01387.x","article-title":"The effect of prebiotics in the management of neonatal hyperbilirubinaemia","volume":"98","author":"Bisceglia","year":"2009","journal-title":"Acta paediatr"},{"issue":"2","key":"10.3233\/NPM-210847_ref21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/14767058.2012.725115","article-title":"Impact of probiotics on the course of indirect hyperbilirubinemia and phototherapy duration in very low birth weight infants","volume":"26","author":"Demirel","year":"2013","journal-title":"JMatern Fetal Neonatal Med"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NPM-210847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:41:59Z","timestamp":1777614119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/NPM-210847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":20,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/npm-210847","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,12]]}}}