{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:13:55Z","timestamp":1787948035581,"version":"build-2784847793"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2022,4,12]]},"abstract":"<jats:p>BACKGROUND: Neonatal hypoglycemia management in the first 48 hours is guided by the American Academy of Pediatrics (AAP) and Pediatric Endocrine Society (PES) recommendations. Our aim was to determine the incidence of hypoglycemia via point of care test (POCT) on the 2nd day of life (DOL) among healthy, asymptomatic neonates regardless of risk factors. METHODS: In this prospective observational study, preprandial point of care glucose concentration was measured on the 2nd DOL in 150 healthy, asymptomatic neonates in the newborn nursery. We used 50\u200amg\/dl (2.8\u200ammol\/L) as the hypoglycemia threshold based on PES recommendations. RESULTS: The incidence of hypoglycemia on the second DOL was 10% among asymptomatic neonates (no risk factors\u200a=\u200a8%; late preterm birth (LPT)\u200a+\u200asmall for gestational age (SGA)\u200a=\u200a16%; large for gestational age (LGA)\u200a+\u200ainfant of diabetic mother (IDM)\u200a=\u200a6%). SGA\u200a+\u200aLPT neonates accounted for the majority of the hypoglycemic cases (53.3%) and exhibited a trend towards the lowest glucose concentration (p\u200a=\u200a0.09). CONCLUSION: The incidence of hypoglycemia on DOL 2 among asymptomatic neonates is high and of unclear significance in the absence of dedicated neurodevelopmental follow-up.<\/jats:p>","DOI":"10.3233\/npm-210861","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T12:39:42Z","timestamp":1640695182000},"page":"311-316","source":"Crossref","is-referenced-by-count":5,"title":["Hypoglycemia screening of asymptomatic newborns on the 2nd day of life"],"prefix":"10.1177","volume":"15","author":[{"given":"H.","family":"Karbalivand","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iyare","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Aponte","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Xianhong","sequence":"additional","affiliation":[{"name":"Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Havranek","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"1","key":"10.3233\/NPM-210861_ref1","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1542\/neo.21-1-e14","article-title":"Glucose homeostasis in newborns: An endocrinology perspective","volume":"21","author":"Tas","year":"2020","journal-title":"Neoreviews"},{"issue":"6","key":"10.3233\/NPM-210861_ref2","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0022-3476(81)80583-5","article-title":"Variation in plasma ketone bodies during a 24 fast in normal and in hypoglycemic children: Relationship to age","volume":"98","author":"Saudubray","year":"1981","journal-title":"J Pediatr"},{"key":"10.3233\/NPM-210861_ref3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1542\/peds.2010-3851","article-title":"Postnatal glucose homeostasis in late-preterm and term infants","volume":"127","author":"Adamkin","year":"2011","journal-title":"Pediatrics"},{"key":"10.3233\/NPM-210861_ref4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/pch\/pxz134","article-title":"The screening and management of newborns at risk for low blood glucose","volume":"24","author":"Narvey","year":"2019","journal-title":"Paediatr Child Health"},{"key":"10.3233\/NPM-210861_ref5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jpeds.2015.03.057","article-title":"Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children","volume":"167","author":"Thornton","year":"2015","journal-title":"J Pediatr"},{"key":"10.3233\/NPM-210861_ref6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1542\/pir.2016-0063","article-title":"Neonatal hypoglycemia","volume":"38","author":"Thompson-Branch","year":"2017","journal-title":"Pediatr Rev"},{"key":"10.3233\/NPM-210861_ref7","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bmj.297.6659.1304","article-title":"Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia","volume":"297","author":"Lucas","year":"1988","journal-title":"BMJ"},{"key":"10.3233\/NPM-210861_ref8","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1001\/jamapediatrics.2017.1579","article-title":"Association of Neonatal Hypoglycemia Outcomes at 4.5 years","volume":"171","author":"McKinlay","year":"2017","journal-title":"JAMA Pediatr"},{"key":"10.3233\/NPM-210861_ref9","first-page":"261","article-title":"Hypoglycaemia of the newborn","volume":"75","author":"Williams","year":"1997","journal-title":"Bull World health Organ"},{"key":"10.3233\/NPM-210861_ref10","first-page":"195","article-title":"Outcome of neonatal glycemia [letter]","volume":"318","author":"Lucas","year":"1999","journal-title":"BMJ"},{"key":"10.3233\/NPM-210861_ref11","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1542\/peds.2012-0776","article-title":"15 year follow -up of recurrent \u201chypoglycemia\u201d in preterm infants","volume":"130","author":"Tin","year":"2012","journal-title":"Pediatrics"},{"issue":"2","key":"10.3233\/NPM-210861_ref12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pcl.2018.12.004","article-title":"Hypoglycemia in the newborn","volume":"66","author":"Rozance","year":"2019","journal-title":"Pediatr Clin North Am"},{"key":"10.3233\/NPM-210861_ref13","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/s41372-020-0641-1","article-title":"Clinical impact of neonatal hypoglycemia screening in the well-baby care","volume":"40","author":"Mukhopadhyay","year":"2020","journal-title":"J Perinatol"},{"issue":"5","key":"10.3233\/NPM-210861_ref14","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jpeds.2012.05.022","article-title":"Incidence of neonatal hypoglycemia in babies identified as at risk","volume":"161","author":"Harris","year":"2012","journal-title":"J Pediatr"},{"key":"10.3233\/NPM-210861_ref15","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/S0140-6736(13)61645-1","article-title":"Dextrose gel for neonatal hypoglycaemia (the Sugar Babies Study): A randomised, double-blind, placebo-controlled trial","volume":"382","author":"Harris","year":"2013","journal-title":"Lancet"},{"key":"10.3233\/NPM-210861_ref16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpeds.2020.02.079","article-title":"Glucose profiles in healthy term infants in the first 5 days: The glucose in well babies (GLOW) study","volume":"223","author":"Harris","year":"2020","journal-title":"J Pediatr"},{"key":"10.3233\/NPM-210861_ref17","doi-asserted-by":"crossref","first-page":"F46","DOI":"10.1136\/fn.87.1.F46","article-title":"Plasma glucose levels in term infants who are appropriate size for gestation and exclusively breast fed","volume":"87","author":"Diwakar","year":"2002","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.3233\/NPM-210861_ref18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-3476(87)80303-7","article-title":"Serum glucose levels in term neonates during the first 48 hours of life","volume":"110","author":"Heck","year":"1987","journal-title":"J Pediatr"},{"key":"10.3233\/NPM-210861_ref19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jpeds.2017.06.034","article-title":"What happens to blood glucose concentrations after oral treatment for neonatal hypoglycemia?","volume":"190","author":"Harris","year":"2017","journal-title":"J Pediatr"},{"key":"10.3233\/NPM-210861_ref20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jpeds.2017.08.025","article-title":"Searching for the best oral treatment for hypoglycemic newborns","volume":"190","author":"Rozance","year":"2017","journal-title":"J Pediatr"},{"key":"10.3233\/NPM-210861_ref21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/193229681200600228","article-title":"Accuracy of point-of-care glucose measurements","volume":"6","author":"Rebel","year":"2012","journal-title":"J Diabetes Sci Technol"},{"key":"10.3233\/NPM-210861_ref22","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1001\/jamapediatrics.2020.0632","article-title":"Guidelines for management of neonatal hypoglycemia: Are they actually applicable?","volume":"174","author":"Dani","year":"2020","journal-title":"JAMA Pediatr"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NPM-210861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:42:02Z","timestamp":1777614122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/NPM-210861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":22,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/npm-210861","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,12]]}}}