{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:22:28Z","timestamp":1780503748671,"version":"3.54.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2022,8,22]]},"abstract":"<jats:p>BACKGROUND: We aimed to explore the epidemiology and evolution of pathogens, antibiotic susceptibility, and mortality rate in cases of neonatal early-onset sepsis (EOS) reported over a period of 12 years in a level III neonatal center in Central Taiwan. METHODS: Patients\u2019 medical records in a neonatal center from 2007 to 2018 were reviewed to obtain information on infants with culture-proven EOS, which included pathogens found in the blood or cerebrospinal fluid cultures. RESULTS: The incidence of neonatal EOS during this period was 2.11 cases\/1,000 admissions. Group B streptococcal (GBS) and Escherichia coli were the most common pathogens. The overall rates of GBS and E. coli infections were 0.68\/1,000 and 0.77\/1,000 live births, respectively. The incidence of EOS in infants with a birth weight \u22651,500\u200ag decreased significantly with decreasing incidence of GBS-related sepsis. The incidence of EOS remained high in very-low-birth-weight (VLBW) infants and increased over time. There was an increasing trend in of E. coli infection and emergence of drug-resistant strains. In addition, E. coli sepsis had high mortality in VLBW infants. CONCLUSION: Novel screening and prevention strategies against E. coli and reserving broad-spectrum antibiotics for the most critically ill or VLBW patients with maternal chorioamnionitis might help in early diagnosis and further improve the outcomes of EOS.<\/jats:p>","DOI":"10.3233\/npm-210938","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T11:28:47Z","timestamp":1649158127000},"page":"575-582","source":"Crossref","is-referenced-by-count":6,"title":["Epidemiological evolution of early-onset neonatal sepsis over 12 years: A single center, population-based study in central Taiwan"],"prefix":"10.1177","volume":"15","author":[{"given":"I-Chun","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Neonatology, China Medical University Children\u2019s Hospital, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chia","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Healthcare Administration, College of Medical and Health Sciences, Asia University, Taichung, Taiwan"},{"name":"Department of Long Term Care, College of Health and Nursing, National Quemoy University, Kinmen County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Neonatology, China Medical University Children\u2019s Hospital, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Neonatology, China Medical University Children\u2019s Hospital, China Medical University, Taichung, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Yu","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Neonatology, China Medical University Children\u2019s Hospital, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Luen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Neonatology, China Medical University Children\u2019s Hospital, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chih","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Neonatology, China Medical University Children\u2019s Hospital, China Medical University, Taichung, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Pediatrics, Asia University Hospital, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/NPM-210938_ref1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.siny.2017.02.006","article-title":"Early neonatal death: A challenge worldwide","volume":"22","author":"Lehtonen","year":"2017","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.3233\/NPM-210938_ref2","first-page":"817","article-title":"Early onset neonatal sepsis: The burden of group B streptococcal and E","volume":"127","author":"Stoll","year":"2011","journal-title":"coli disease continues. 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