{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:30:38Z","timestamp":1777890638103,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2022,8,22]]},"abstract":"<jats:p>BACKGROUND: Jaundice is the quite common benign condition in neonates, but due to its potential toxicity, neonates must be monitored. This study was aimed to evaluate the effect of serum albumin level on the transcutaneous bilirubin (TcB) measurements in term neonates with unconjugated hyperbilirubinemia. METHODS: Serum albumin and total serum bilirubin (TSB) of 252 jaundiced term neonates were estimated and simultaneously TcB was measured over sternum and the effect of serum albumin on TcB measurements was evaluated. RESULTS: The correlation between TSB and TcB was linear and significant for the entire cohort. When this correlation was studied separately in the groups with different albumin levels, maximum correlation (r\u200a=\u200a0.888, R2 linear\u200a=\u200a0.789, p\u200a&lt;\u200a0.001) was observed in group 1 with hypo-albuminemia followed by in group 2 with normal albumin levels (r\u200a=\u200a0.854, R2 linear\u200a=\u200a0.729, p\u200a&lt;\u200a0.001) and group 3 with higher albumin levels (r\u200a=\u200a0.809, R2 linear\u200a=\u200a0.689, p\u200a&lt;\u200a0.001). Bland-Altman plot analysis of whole study population demonstrate good agreement between TSB and TcB [95% CI\u200a=\u200a\u20130.038 to 0.493\u200amg\/dL, 17\/252\u200a=\u200a6.75% outside the limits of agreement, Mean difference\u200a=\u200a0.227]. This analysis in different groups also show good agreement between TSB and TcB. CONCLUSIONS: The correlation between the TSB and TcB may affected by serum albumin level. Therefore, transcutaneous bilirubinometry is not able to replace invasive TSB measurement. However, in the absence of TSB it could be an alternative to measure the level of bilirubin in term neonates.<\/jats:p>","DOI":"10.3233\/npm-210958","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T13:03:47Z","timestamp":1648213427000},"page":"609-615","source":"Crossref","is-referenced-by-count":1,"title":["Can serum albumin level affect the transcutaneous bilirubinometry in term neonates?"],"prefix":"10.1177","volume":"15","author":[{"given":"D.","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"4","key":"10.3233\/NPM-210958_ref1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1542\/peds.94.4.558","article-title":"Practice parameter: Management of hyperbilirubinemia in the healthy term newborn","volume":"94","author":"American Academy of Pediatrics, Provisional Committee for Quality Improvement and subcommittee on Hyperbilirubinemia","year":"1994","journal-title":"Pediatrics"},{"issue":"1","key":"10.3233\/NPM-210958_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-9120(96)00131-2","article-title":"Transcutaneous bilirubinometry: Its role in the assessment of neonatal jaundice","volume":"30","author":"Dai","year":"1997","journal-title":"Clin Biochem"},{"issue":"3","key":"10.3233\/NPM-210958_ref3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/fn.86.3.F190","article-title":"Can transcutaneous bilirubinometry reduce the need for blood tests in jaundiced full term babies?","volume":"86","author":"Briscoe","year":"2002","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"10.3233\/NPM-210958_ref4","first-page":"217","article-title":"Historical perspectives: Transcutaneous bilirubinometry","volume":"7","author":"Maisels","year":"2006","journal-title":"Neo Reviews"},{"key":"10.3233\/NPM-210958_ref5","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1542\/peds.2009-0329","article-title":"Hyperbilirubinemia in the newborn infant >or =35 weeks\u2019 gestation: An update with clarifications","volume":"124","author":"Maisels","year":"2009","journal-title":"Pediatrics"},{"issue":"1","key":"10.3233\/NPM-210958_ref6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1651-2227.1993.tb12507.x","article-title":"Effect of melanin, oxyhemoglobin and bilirubin on transcutaneous bilirubinometry","volume":"82","author":"Onks","year":"1993","journal-title":"Acta Paediatr"},{"issue":"3","key":"10.3233\/NPM-210958_ref7","first-page":"171","article-title":"Newborns bilirubin concentration determined by different methods in relation to hematocrit and albumin level","volume":"39","author":"Berska","year":"2020","journal-title":"J Med Biochem"},{"issue":"1","key":"10.3233\/NPM-210958_ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40748-017-0070-0","article-title":"Evaluation of transcutaneous bilirubinometer use in Zimbabwean newborn babies","volume":"4","author":"Chimhini","year":"2018","journal-title":"Matern Health Neonatol Perinatol"},{"key":"10.3233\/NPM-210958_ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14767058.2020.1849112","article-title":"The accuracy of transcutaneous bilirubin to identify hyperbilirubinemia in jaundiced neonates","volume":"11","author":"Ying","year":"2020","journal-title":"J Matern. 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