{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:43:51Z","timestamp":1789847031268,"version":"4.0.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2022,12,23]]},"abstract":"<jats:p>BACKGROUND: To determine the clinical implications and gestation age-specific diagnostic predictability of pneumatosis in preterm infants with necrotizing enterocolitis (NEC). METHODS: A retrospective study on abdominal radiographs comparing clinical and radiological information in infants with and without pneumatosis. RESULT: Our findings disproved our hypothesis. Pneumatosis was seen more frequently in infants with higher gestational age [28.4 (26.1\u201332.4) vs. 26.4 (24.3\u201329) weeks; p\u200a&lt;\u200a0.001] and birth weight [1110 (762\u20131768) vs. 770 (645\u20131022) grams; p\u200a&lt;\u200a0.001] and were more likely delivered vaginally (39.1% vs. 21.7%, p\u200a=\u200a0.01). Portal venous gas was seen frequently on radiographs (10.3% vs. 0%, p\u200a&lt;\u200a0.001), but not pneumoperitoneum (20.7% vs. 36.7%, p\u200a=\u200a0.02). Infants with pneumatosis frequently developed acute kidney injury, with higher serum creatinine (16.5% vs. 4.5%, p\u200a=\u200a0.02) and frequent oliguria (12.9% vs. 2.7 %; p\u200a=\u200a0.043) and had higher C-reactive protein levels at 24 and 96 hours (p\u200a&lt;\u200a0.002). Receiver operating curves for pneumatosis showed GA &gt;28 weeks and birth weight &gt;\u200a1000\u200agm to have a sensitivity of 58.6% and specificity of 72.5%. CONCLUSION: Contrary to our hypothesis, infants who developed pneumatosis during NEC were more mature with a higher gestational age and birth weight than those who did not.<\/jats:p>","DOI":"10.3233\/npm-210971","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T11:42:10Z","timestamp":1657021330000},"page":"803-812","source":"Crossref","is-referenced-by-count":5,"title":["Clinical outcomes and gestational age based prediction of pneumatosis intestinalis in preterm infants with necrotizing enterocolitis"],"prefix":"10.1177","volume":"15","author":[{"given":"P.M.","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Pediatrics\/Neonatology, University of Mississippi, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Paschal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Neonatology, University of Mississippi, Jackson, MS, 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