{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:32:58Z","timestamp":1792618378610,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:p>BACKGROUND: Reference guidelines for neonatal conjugated hyperbilirubinemia (cholestasis) management use a uniform approach regardless of gestational age (GA). We hypothesize that the clinical pattern of neonatal cholestasis is tightly related to GA. The aim of this study was to describe the effects of GA on neonatal cholestasis. METHODS: A retrospective 4-year cohort study in a 70-bed neonatal care unit. Neonates with conjugated bilirubin\u226534.2\u03bcmol\/L (2\u200amg\/dL) were identified. The incidence, clinical characteristics, etiology, treatment, and prognosis were compared between infants\u200a&lt;32 and\u226532 weeks GA. RESULTS: Overall incidence of cholestasis was 4% (125\/3402). It was\u200a&gt;5 times higher and the mean duration was\u200a&gt;1.5 times longer in neonates\u200a&lt;32 weeks GA (10% versus 1.8%, p\u200a&lt;0.01 and 49 versus 31 days, p\u200a&lt;0.01, respectively). The onset of cholestasis was later in neonates\u200a&lt;32 weeks (22 versus 10 days of life, p\u200a&lt;0.001). This later onset of cholestasis was associated with parenteral nutrition, whereas the earlier onset was associated with other causes. Treatment using fish oil lipids was more frequently administrated to infants\u200a&lt;32 weeks GA, whereas Ursodeoxycholic acid was administrated more frequently in\u226532 weeks GA. Cholestasis resolved during hospitalization in 73% of\u200a&lt;32 versus 38% in\u226532 weeks GA infants (p\u200a&lt;0.01). CONCLUSIONS: The incidence, clinical presentation, etiology, treatment, and clinical evolution of neonatal cholestasis were all significantly affected by GA. Our results support the use of a GA-oriented approach for the management of neonatal cholestasis.<\/jats:p>","DOI":"10.3233\/npm-230034","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:14:30Z","timestamp":1705403670000},"page":"101-110","source":"Crossref","is-referenced-by-count":2,"title":["The effects of gestational age on neonatal cholestasis: A retrospective cohort study"],"prefix":"10.1177","volume":"17","author":[{"given":"N.","family":"El Raichani","sequence":"first","affiliation":[{"name":"Department of Nutrition, University of Montreal, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Thibault","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, CHU Sainte-Justine, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics-Gastroenterology, Hepatology and Nutrition, CHU Sainte-Justine, University of Montreal, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-C.","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Montreal, Montreal, QC, Canada"},{"name":"Departments of Pediatrics-Neonatology, CHU Sainte-Justine, University of Montreal, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Montreal, Montreal, QC, Canada"},{"name":"Departments of Pediatrics-Neonatology, CHU Sainte-Justine, University of Montreal, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"1","key":"10.3233\/NPM-230034_ref1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0031-3955(03)00116-0","article-title":"Molecular basis of neonatal cholestasis","volume":"49","author":"Emerick","year":"2002","journal-title":"Pediatr Clin N Am"},{"issue":"5","key":"10.3233\/NPM-230034_ref2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1053\/j.semperi.2004.09.008","article-title":"Neonatal cholestasis","volume":"28","author":"Venigalla","year":"2004","journal-title":"Semin Perinatol"},{"issue":"1","key":"10.3233\/NPM-230034_ref3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0148607113496280","article-title":"Incidence, prevention, and treatment of parenteral nutrition-associated cholestasis and intestinal failure-associated liver disease in infants and children: a systematic review","volume":"38","author":"Lauriti","year":"2014","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"6","key":"10.3233\/NPM-230034_ref4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41575-019-0132-z","article-title":"Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics","volume":"16","author":"Feldman","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"11","key":"10.3233\/NPM-230034_ref5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1542\/pir.25-11-388","article-title":"Neonatal cholestasis","volume":"25","author":"Suchy","year":"2004","journal-title":"Pediatr Rev"},{"issue":"3","key":"10.3233\/NPM-230034_ref7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.clinre.2014.03.010","article-title":"Cholestasis in the newborn and infant","volume":"38","author":"Fischler","year":"2014","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"3","key":"10.3233\/NPM-230034_ref8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1542\/pir.28.3.83","article-title":"Conjugated hyperbilirubinemia: Screening and treatment in older infants and children","volume":"28","author":"Harb","year":"2007","journal-title":"Pediatr Rev"},{"issue":"4","key":"10.3233\/NPM-230034_ref9","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jpeds.2010.09.061","article-title":"Interpreting conjugated bilirubin levels in newborns","volume":"158","author":"Davis","year":"2011","journal-title":"J Pediatr"},{"issue":"6","key":"10.3233\/NPM-230034_ref10","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/MPG.0000000000000739","article-title":"Impact of parenteral fat composition on cholestasis in preterm infants","volume":"60","author":"Teng","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3233\/NPM-230034_ref11","unstructured":"The Canadian Neonatal Network. 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