{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:31:06Z","timestamp":1777890666564,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:p>A circular shunt is a poor prognostic factor associated with Ebstein\u2019s anomaly. Targeting the constriction of the ductus arteriosus (DA) in order to limit or resolve the circular shunt, has been shown to improve fetal outcomes. Prenatal non-steroidal anti-inflammatory drugs (NSAIDs) have been known to constrict the DA. Recently, prenatal NSAIDs have been used for that purpose in the treatment of circular shunt. Limited research shows that it may be an effective treatment leading to improved fetal outcomes. In this article, we did an extensive review of literature to describe this therapy\u2019s effectiveness and outcomes. 82% of fetuses were able to achieve ductal constriction with prenatal NSAID therapy. For fetuses who achieved ductal constriction, fetal demise was less likely (6%) when compared to those who were unable to achieve the same (50%). Of all the fetuses with hydrops, 50% had resoluation of hydrops with prenatal NSAID treatment.<\/jats:p>","DOI":"10.3233\/npm-230040","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T11:51:14Z","timestamp":1704801074000},"page":"63-69","source":"Crossref","is-referenced-by-count":6,"title":["Fetal circular shunt in Ebstein\u2019s anomaly and non-steroidal anti-inflammatory treatment"],"prefix":"10.1177","volume":"17","author":[{"given":"F.L.","family":"Pe\u00f1a","sequence":"first","affiliation":[{"name":"Louisiana State University Health Shreveport, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.W.","family":"Emanuelson","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Shreveport, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Todman","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Shreveport, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Shreveport, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Shreveport, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"2","key":"10.3233\/NPM-230040_ref1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1161\/CIRCULATIONAHA.106.619338","article-title":"Ebstein\u2019s anomaly","volume":"115","author":"Attenhofer Jost","year":"2007","journal-title":"Circulation"},{"key":"10.3233\/NPM-230040_ref2","first-page":"238","article-title":"Uber einen sehr seltenen fall von insufficienz der valvula tricuspidalis, bedingt durch eine angeborene hochgradige misshildung derselben","volume":"33","author":"Ebstein","year":"1866","journal-title":"Arch Anat Physiol"},{"issue":"4","key":"10.3233\/NPM-230040_ref3","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1177\/2150135111416016","article-title":"Current trends in the management of neonates with Ebstein\u2019s anomaly","volume":"2","author":"Goldberg","year":"2011","journal-title":"World J Pediatr Congenit Heart Surg"},{"issue":"1","key":"10.3233\/NPM-230040_ref4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.amjcard.2016.09.022","article-title":"Assessment of progressive pathophysiology after early prenatal diagnosis of the ebstein anomaly or tricuspid valve dysplasia","volume":"119","author":"Selamet Tierney","year":"2017","journal-title":"AM J Cardiol"},{"key":"10.3233\/NPM-230040_ref5","doi-asserted-by":"crossref","unstructured":"Freud LR , McElhinney DB , Kalish BT , Escobar-Diaz MC , Komarlu R , Puchalski MD et al. Risk factors for mortality and circulatory outcome among neonates prenatally diagnosed with ebstein anomaly or tricuspid valve dysplasia: A multicenter study. 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The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. 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