{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:27:17Z","timestamp":1791930437597,"version":"4.3.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:p>BACKGROUND: Nosocomial infections pose a significant health risk to neonates, and traditional biomarkers used for diagnosis often fall short in predicting such infections. In this study, we evaluate the efficacy of the HeRO (Heart Rate Observation score), a novel predictive tool for late-onset neonatal sepsis, in improving neonatal prognosis and reducing morbidity and mortality rates. METHODS: A prospective study was conducted from September 2020 to May 2021, reviewing patient evaluation for all neonates admitted to the neonatal intensive care unit during this period after the implementation of the HeRO score. RESULTS: Of the 100 cases studied, preterm neonates accounted for the majority (51%), with 65% being born at gestational age greater than 32 weeks and 35% born at less than 32 weeks. A male-to-female sex ratio of 1.56. Perinatal asphyxia was the primary reason for initial hospitalization, often accompanied by pulmonary neonatal infection. The HeRO score showed an increase within 24 hours of the onset of clinical signs of sepsis in 52% of cases and after 24 hours in 47% of cases. In 51% of cases, the score exhibited an increase greater than 2. Blood cultures were positive in 91% of cases. The duration of hospital stays for newborns ranged from 7 to 42 days, with an average stay for newborns whose score rose 24 hours before clinical signs. CONCLUSION: This study highlights the significance of utilizing the HeRO score for predicting nosocomial infections in neonates, despite the possibility of false assumptions. Implementing the HERO score enables early intervention, thereby improving the assumption of responsibility and reducing neonatal morbidity and mortality rates.<\/jats:p>","DOI":"10.3233\/npm-230060","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T11:51:27Z","timestamp":1704801087000},"page":"57-62","source":"Crossref","is-referenced-by-count":4,"title":["The HeRO score: Enhancing prognosis and predicting nosocomial infections in newborns: Insights from the neonatal intensive care unit"],"prefix":"10.1177","volume":"17","author":[{"given":"Fatiha","family":"Bennaoui","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother-Child Hospital, CHU Mohammed VI, Marrakech, Morocco"},{"name":"Faculty of Medicine, Childhood, Health and Development Research Unit, Cadi-Ayyad University, Marrakech, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdessamad","family":"Lalaoui","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother-Child Hospital, CHU Mohammed VI, Marrakech, Morocco"},{"name":"Faculty of Medicine, Childhood, Health and Development Research Unit, Cadi-Ayyad University, Marrakech, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"El Idrissi Slitine","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother-Child Hospital, CHU Mohammed VI, Marrakech, Morocco"},{"name":"Faculty of Medicine, Childhood, Health and Development Research Unit, Cadi-Ayyad University, Marrakech, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Soraa","sequence":"additional","affiliation":[{"name":"Microbiology Department, University Hospital Mohammed VI, Marrakech, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadl Mrabih Rabou","family":"Maoulainine","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother-Child Hospital, CHU Mohammed VI, Marrakech, Morocco"},{"name":"Faculty of Medicine, Childhood, Health and Development Research Unit, Cadi-Ayyad University, Marrakech, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"3","key":"10.3233\/NPM-230060_ref1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/pr.2011.45","article-title":"Cytokine screening identifies NICU patients with Gram-negative bacteremia","volume":"71","author":"Raynor","year":"2012","journal-title":"Pediatr Res"},{"issue":"4","key":"10.3233\/NPM-230060_ref2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jpeds.2013.11.038","article-title":"Infection and other clinical correlates of abnormal heart rate characteristics in preterm infants","volume":"164","author":"Sullivan","year":"2014","journal-title":"J Pediatr"},{"issue":"5","key":"10.3233\/NPM-230060_ref3","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1542\/peds.2004-2461","article-title":"Heart rate characteristics: novel physiomarkers to predict neonatal infection and death","volume":"116","author":"Griffin","year":"2005","journal-title":"Pediatrics"},{"key":"10.3233\/NPM-230060_ref4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpeds.2016.03.042","article-title":"Early Heart Rate Characteristics Predict Death and Morbidities in Preterm Infants","volume":"174","author":"Sullivan","year":"2016","journal-title":"J Pediatr"},{"issue":"5","key":"10.3233\/NPM-230060_ref5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00075198-200210000-00002","article-title":"Heart rate variability in critical care medicine","volume":"8","author":"Gang","year":"2002","journal-title":"Curr Opin Crit Care"},{"key":"10.3233\/NPM-230060_ref6","first-page":"5503","article-title":"Continuous Multiorgan Variability monitoring in critically ill patients\u2013complexity science at the bedside","volume":"2011","author":"Seely","year":"2011","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"issue":"1","key":"10.3233\/NPM-230060_ref8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3390\/app11010404","article-title":"Intelligent neonatal sepsis early diagnosis system for very low birth weight infants","volume":"11","author":"Tarricone","year":"2021","journal-title":"Appl Sci"},{"issue":"363","key":"10.3233\/NPM-230060_ref9","doi-asserted-by":"crossref","first-page":"363ra148","DOI":"10.1126\/scitranslmed.aaf8781","article-title":"Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells","volume":"8","author":"Weinberger","year":"2016","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.3233\/NPM-230060_ref10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","article-title":"International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics","volume":"6","author":"Goldstein","year":"2005","journal-title":"Pediatr Crit Care Med"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NPM-230060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:43:13Z","timestamp":1777614193000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/NPM-230060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,4]]},"references-count":9,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/npm-230060","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,4]]}}}