{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:05:03Z","timestamp":1787025903276,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2024,5,16]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Hypernatremia may facilitate the diffusion of bilirubin through the blood-brain barrier and increase the risk of bilirubin encephalopathy. This study was conducted to compare the prognosis of jaundice infants with those with jaundice and hypernatremia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A total of 615 term infants with idiopathic jaundice with or without hypernatremia were enrolled in this cohort study with 24-months follow-up at Ghaem Hospital, Mashhad, Iran, between 2010 and 2022. An in-house questionnaire including the laboratory evaluation and neonatal characteristics was used as the data collection tool. The follow-up of neonatal development status was performed using the Denver test II at 6, 12, 18, and 24 months after discharging from hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Normal outcomes were seen in 555 (90.2%) out of 615 studied infants, while 60 cases (9.8%) showed abnormal outcomes. Serum levels of sodium ( P\u200a=\u200a0.017), bilirubin ( P\u200a=\u200a0.001), urea ( P\u200a=\u200a0.024), and creatinine ( P\u200a=\u200a0.011) as well as hyperthermia ( P\u200a=\u200a0.046) and unconsciousness ( P\u200a=\u200a0.005) showed significant differences between the two groups. Approximately 16% of the newborns with both jaundice and hypernatremia, and 9% of those with only jaundice had unfavorable prognoses. Also, bilirubin level had the most predictive power (91.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our results suggest that hypernatremia or jaundice alone, may affect the prognosis of infants aged 2 years; but jaundice and hypernatremia together, will intensify the developmental problems in jaundice infants. However, the role of hyperbilirubinemia in the incidence of complications is more than hypernatremia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/npm-230144","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:43:17Z","timestamp":1715953397000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of prognosis between hyperbilirubinemic infants with and without hypernatremia"],"prefix":"10.1177","volume":"17","author":[{"given":"M.","family":"Zakerihamidi","sequence":"first","affiliation":[{"name":"Department of Midwifery, School of Medical Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moradi","sequence":"additional","affiliation":[{"name":"Orthopedic Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ramazani","sequence":"additional","affiliation":[{"name":"Mashhad Ghaem Hospital, Ward of Neonatal Intensive Care Unit, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Boskabadi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"issue":"3","key":"ref001","first-page":"197","volume":"15","author":"Ahmadpour M","year":"2005","journal-title":"J Dis Iran"},{"issue":"9","key":"ref002","volume":"17","author":"Boskabadi H","year":"2015","journal-title":"J Babol Univ Med 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