{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:31:32Z","timestamp":1777890692617,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:p>BACKGROUND: Persistent pulmonary hypertension of the neonate (PPHN) is a serious disorder. The long pentraxin 3 (PTX3) plays an important role in angiogenesis, cell proliferation, tissue repair and cell regulation. The present study aims to assess the diagnostic and clinical value of PTX3 in PPHN. METHODS: The present case-control 60 full-term neonates diagnosed with PPHN by echocardiography within 72 hours of birth. In addition, there were 30 age and sex-matched healthy neonates who served as controls. All participants were subjected to careful history taking and complete clinical examination, Laboratory investigations included complete blood count, C-reactive protein (CRP), blood culture and PTX3 level. Radiological investigations included plain X- ray and two-dimensional transthoracic echocardiography (TTE). RESULTS: Comparison between patients and controls revealed that patients had significantly higher CRP (6.12\u00b12.18 versus 3.69\u00b11.25\u200amg\/dl, p\u00a0&lt;\u00a00.001) and PTX3 levels (2.07\u00b10.67 versus 0.96\u00b10.21, p\u00a0&lt;\u00a00.001) when compared with controls. Patients with associated PDA had significantly higher PTX3 levels when compared with patients without (2.58\u00b10.5 versus 2.02\u00b10.51\u200ang\/ml, p\u200a=\u200a0.002). Also, patients with associated PFO had significantly higher PTX3 levels when compared with patients without (2.12\u00b11.05 versus 2.05\u00b10.46, p\u200a=\u200a0.002). ROC curve analysis identified good performance of CRP and PTX3 levels in diagnosis of PPHN with PTX3 showing better performance. CONCLUSIONS: There is a significant association between serum PTX3 levels and PPHN particularly those with associated PDA or PFO.<\/jats:p>","DOI":"10.3233\/npm-230211","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T11:35:13Z","timestamp":1708688113000},"page":"7-11","source":"Crossref","is-referenced-by-count":2,"title":["Serum pentraxin 3 levels in term neonates with persistent pulmonary hypertension"],"prefix":"10.1177","volume":"17","author":[{"given":"A.E.A.","family":"Asal","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Neonatology, Faculty of Medicine, Al-Azhar University (for girls), Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.F.","family":"Oshaiba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Faculty of Medicine, Al-Azhar University (for girls), Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.N.A.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Faculty of Medicine, Al-Azhar University (for girls), Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.H.","family":"Abd Elaziz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Al-Azhar University (for girls), Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.A.","family":"Nasr","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University (for girls), Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"3","key":"10.3233\/NPM-230211_ref1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2165\/00148581-200608030-00004","article-title":"Persistent pulmonary hypertension of 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