{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:31:36Z","timestamp":1777890696163,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2023,10,11]]},"abstract":"<jats:p>BACKGROUND: Systemic candidiasis is an important nosocomial infection in neonatal intensive care units. The objective of this study was to identify the change in the profile of neonatal candidiasis in a tertiary neonatal intensive care unit (NICU) in eastern India in recent times. METHODS: It was a retrospective review of case records from 2014 to 2019 from a tertiary NICU of eastern India. Data of the fungal sepsis, demographic details, risk factors of fungal sepsis and mortality were collected from 103 neonates. RESULTS: One hundred and three neonates had blood culture positive for fungal species of which 91 (88.3%) infants weighed \u22651500\u200ag and 66 (64%) infants were term. There was significant higher incidence of candidiasis among outborn (Relative risk of outborn 18.84, 95% CI 10.74\u201333.05). Prolonged antibiotic usage (&gt;14 days), meropenem usage (&gt;5 days), central catheterization (&gt;5 days), invasive mechanical ventilation (&gt;5 days), surgical intervention were found in 64 (62.1%), 46 (44.6%), 31(30.0%), 40 (38.8%) and 39 (37.8%) infants. Non albicans candida (NAC) was isolated as the predominant species (82\/103, 79.6%). Resistance to both of fluconazole and amphotericin B were found in 19 (18.4%) babies. Presence of NAC infection and resistance to both amphotericin B and fluconazole were independent predictors of candida associated mortality in NICU. CONCLUSION: Neonatal candidiasis is found among outborn infants with higher birth weight and gestational age. NAC species are predominant organisms with resistance to common antifungal drugs.<\/jats:p>","DOI":"10.3233\/npm-231204","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:23:10Z","timestamp":1694776990000},"page":"501-506","source":"Crossref","is-referenced-by-count":3,"title":["Profile of neonatal candidiasis in tertiary neonatal intensive care unit: A report from a developing country"],"prefix":"10.1177","volume":"16","author":[{"given":"A.K.","family":"Saha","sequence":"first","affiliation":[{"name":"Department of Neonatology, Institute of Post-Graduate Medical Education & Research and SSKM Hospital, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Institute of Post-Graduate Medical Education & Research and SSKM Hospital, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"2","key":"10.3233\/NPM-231204_ref1","first-page":"1006","article-title":"Early Diagnosis of Neonatal Sepsis caused by Yeast Infection","volume":"1","author":"Mokhtar","year":"2014","journal-title":"Austin J Public Health Epidemiol"},{"issue":"7B","key":"10.3233\/NPM-231204_ref2","first-page":"2583","article-title":"An emerging threat of Non-Albicans Candida Infection in Tertiary care neonatal intensive care units","volume":"3","author":"Niranjan","year":"2015","journal-title":"Sch J App Med Sci"},{"issue":"1","key":"10.3233\/NPM-231204_ref3","first-page":"27","article-title":"Systemic fungal infections","volume":"51","author":"Rao","year":"2005","journal-title":"J Postgrad Med"},{"issue":"6","key":"10.3233\/NPM-231204_ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0180705","article-title":"Alarming rates of antimicrobial resistance and fungal sepsis in outborn neonates in North India","volume":"13","author":"Jajoo","year":"2018","journal-title":"PloS One"},{"key":"10.3233\/NPM-231204_ref5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2431-5-22","article-title":"Variations in rates of nosocomial infection among Canadian neonatal intensive care units may be practice related","volume":"5","author":"Aziz","year":"2005","journal-title":"BMC Pediatrics"},{"issue":"5","key":"10.3233\/NPM-231204_ref6","first-page":"626","article-title":"Canadian Neonatal Network","volume":"146","author":"Shah","year":"2005","journal-title":"Improved outcomes of outborn preterm infants if admitted to perinatal centers versus free standing pediatric hospitals. 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