{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:43:11Z","timestamp":1785253391282,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2023,6,27]]},"abstract":"<jats:p>BACKGROUND: Poractant administration with thin catheter is gradually gaining popularity compared to the INSURE technique. However, there is little evidence to use thin catheters for administration of beractant. With this background, we compared the effect of beractant administration with INSURE vs thin catheter in preterm infants less than 34 weeks with RDS on death\/chronic lung disease (CLD). METHODS: This prospective cohort study was conducted in a tertiary NICU where inborn preterm infants\u226434 weeks with RDS receiving beractant by INSURE or thin catheter were studied over two epochs- Epoch1\u2013 INSURE (Jan 2020\u2013Oct 2020) &amp; Epoch 2\u2013 Surfactant through thin catheter (Nov 2020\u2013July 2021).The primary outcome was occurrence of death\/CLD. Procedure related complications like transient bradycardia\/desaturation, pneumothorax, failure of procedure, rates of other outcomes like failure of CPAP within 72hr, duration of invasive mechanical ventilation\/ CPAP support, oxygen supplementation, other major neonatal morbidities &amp; mortality were evaluated as secondary outcomes. RESULTS: The combined outcome of death\/CLD was significantly lower in the thin catheter epoch (RR 0.56, 95% CI 0.34-0.90, p\u200a=\u200a0.012). When analyzed independently for death\/CLD, we found significantly lower number of deaths in the thin catheter epoch (RR 0.44, 95% CI 0.23-0.83, p\u200a=\u200a0.008). Number of infants who failed CPAP within 72\u200ahrs of life was lower in thin catheter epoch (RR 0.59, 95% CI 0.41-0.85, p\u200a=\u200a0.003). Transient bradycardia\/desaturation was higher during thin catheter technique (RR 4.17, 95% CI 2.22-7.69, p\u200a&lt;\u200a0.001). Incidence of severe IVH was lower with thin catheter technique (RR 0.13, 95% CI 0.02-0.98, p\u200a=\u200a0.034). CONCLUSION: Beractant administration by thin catheter reduces combined outcome of death\/CLD.<\/jats:p>","DOI":"10.3233\/npm-231205","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T11:31:12Z","timestamp":1685446272000},"page":"239-245","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Beractant Administration by Thin Catheter vs Intubation-Surfactant-Extubation (INSURE) in Preterm Infants Less than 34 Weeks Gestational Age with Respiratory Distress Syndrome \u2013 A Single Centre Experience"],"prefix":"10.1177","volume":"16","author":[{"given":"S.","family":"Patra","sequence":"first","affiliation":[{"name":"Department of Neonatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Manerkar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kalathingal","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kalamdani","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bhisikar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mondkar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"6","key":"10.3233\/NPM-231205_ref1","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.1111\/apa.12611","article-title":"Minimally invasive surfactant therapy with a gastric tube is as effective as the intubation, surfactant, and extubation technique in preterm infants","volume":"103","author":"Aguar","year":"2014","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.3233\/NPM-231205_ref2","doi-asserted-by":"crossref","first-page":"e502","DOI":"10.1542\/peds.2012-0603","article-title":"Surfactant administration via thin catheter during spontaneous breathing: randomized controlled 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bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome: The OPTIMIST-A randomized clinical trial. JAMA"},{"issue":"4","key":"10.3233\/NPM-231205_ref14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S2352-4642(19)30405-5","article-title":"Less invasive surfactant administration: A word of caution","volume":"4","author":"De","year":"2020","journal-title":"Lancet Child Adolesc Health"},{"issue":"11","key":"10.3233\/NPM-231205_ref15","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1111\/apa.16499","article-title":"Multi-centre randomized trial of invasive and less invasivesurfactant delivery methods showed similar spirometry results at5\u20139 years of age","volume":"111","author":"G\u00f6pel","year":"2022","journal-title":"Acta Paediatr"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NPM-231205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:43:54Z","timestamp":1777614234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/NPM-231205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":15,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/npm-231205","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]}}}