{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:28:39Z","timestamp":1788910119249,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NPM"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:p>A\u0130M: Late-onset neonatal sepsis has a high mortality rate in premature infants. To date, no single test in the evaluation of neonatal sepsis has been demonstrated to be both sensitive and specific enough to assist in timely decision making. The aim of our study is to develop a predictive model that can be applied to all premature babies, using clinical and laboratory findings in premature babies, to recognize late-onset neonatal sepsis. STUDY DES\u0130GN: 65 premature patients diagnosed with culture-proven late-onset neonatal sepsis and hospitalized in Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital neonatal intensive care unit between January 2018 and December 2020, and 65 premature newborns of similar age and gender who did not have sepsis were included in the study retrospectively. RESULTS: In our study, feeding difficulties, worsening in clinical appearance and fever were found to be significant among clinical findings, while thrombocytopenia and high C-reactive protein among laboratory findings are the strongest data supporting late-onset neonatal sepsis. In multiple regression analysis, thrombocytopenia, mean platelet volume, C-reactive protein, lymphocyte count and feeding difficulties had the highest odds ratio (p\u200a&lt;\u200a0.05). By converting these data into a scoring system, a nomogram was created that can be easily used by all clinicians. CONCLUSION: In our study, we developed a scoring system that can be easily applied to all premature patients by evaluating the clinical and laboratory findings in late-onset neonatal sepsis. We think that it will help in recognizing late-onset neonatal sepsis and strengthening the treatment decision. Predicting the individual probability of sepsis in preterm newborns may provide benefits for uninfected newborns to be exposed to less antibiotics, not to be separated from mother and baby, and to reduce healthcare system expenditures. The nomogram can be used to assess the likelihood of sepsis and guide treatment decision.<\/jats:p>","DOI":"10.3233\/npm-240011","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T13:13:02Z","timestamp":1728393182000},"page":"661-671","source":"Crossref","is-referenced-by-count":3,"title":["Prediction model for early diagnosis of late-onset sepsis in preterm newborns"],"prefix":"10.1177","volume":"17","author":[{"given":"D.","family":"Seyhanl\u0131","sequence":"first","affiliation":[{"name":"University of Health Sciences, Izmir Faculty of Medicine, Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training Research Hospital, Child Health and Diseases Clinic, Izmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"G\u00f6kmen Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Izmir Faculty of Medicine, Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training Research Hospital, Newborn Intensive Care Unit, \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.H.","family":"Kalkanl\u0131","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Izmir Faculty of Medicine, Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training Research Hospital, Newborn Intensive Care Unit, \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Soysal","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Izmir Faculty of Medicine, Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training Research Hospital, Newborn Intensive Care Unit, \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Alkan \u00d6zdemir","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Izmir Faculty of Medicine, Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training Research Hospital, Newborn Intensive Care Unit, \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130.","family":"Devrim","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Izmir Faculty of Medicine, Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training Research Hospital, Pediatric Infectious Diseases Clinic, \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015e.","family":"\u00c7alkavur","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Izmir Faculty of Medicine, Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training Research Hospital, Newborn Intensive Care Unit, \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"Suppl 1","key":"10.3233\/NPM-240011_ref1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jped.2019.10.004","article-title":"The challenges of neonatal sepsis management","volume":"96","author":"Procianoy","year":"2020","journal-title":"J Pediatr (Rio J)"},{"issue":"3","key":"10.3233\/NPM-240011_ref2","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1136\/archdischild-2014-306213","article-title":"Late-onset neonatal sepsis: Recent developments","volume":"100","author":"Dong","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"2","key":"10.3233\/NPM-240011_ref3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/MOP.0000000000000315","article-title":"Defining neonatal sepsis","volume":"28","author":"Wynn","year":"2016","journal-title":"Curr Opin Pediatr"},{"issue":"Supp: 1","key":"10.3233\/NPM-240011_ref4","first-page":"88","article-title":"T\u00fcrk Neonatoloji Derne\u011fi yenido\u011fan enfeksiyonlar\u0131 tan\u0131 ve tedavi rehberi","volume":"53","author":"Satar","year":"2018","journal-title":"Turk Arch Pediatr"},{"issue":"5","key":"10.3233\/NPM-240011_ref5","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/14656566.2020.1721464","article-title":"Current and emerging treatments for neonatal sepsis","volume":"21","author":"Carbone","year":"2020","journal-title":"Expert Opin Pharmacother"},{"issue":"4","key":"10.3233\/NPM-240011_ref6","first-page":"171","article-title":"Yenido\u011fan sepsisinin erken tan\u0131s\u0131nda C-reaktif protein ve interl\u00f6kin-6\u2019n\u0131n rol\u00fc","volume":"39","author":"\u015eahin","year":"2004","journal-title":"Turk Arch Pediatr"},{"issue":"9","key":"10.3233\/NPM-240011_ref7","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/s41372-020-0649-6","article-title":"Can we improve early identification of neonatal late-onset sepsis? A validated prediction model","volume":"40","author":"Goldberg","year":"2020","journal-title":"J Perinatol"},{"issue":"5","key":"10.3233\/NPM-240011_ref8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/14787210.2020.1732818","article-title":"Neonatal sepsis in low-income countries: Epidemiology, diagnosis and prevention","volume":"18","author":"Popescu","year":"2020","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"11","key":"10.3233\/NPM-240011_ref9","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1542\/neo.23-10-e738","article-title":"Updates in Late-Onset Sepsis: Risk assessment, therapy, and outcomes","volume":"23","author":"Coggins","year":"2022","journal-title":"Neoreviews"},{"issue":"8","key":"10.3233\/NPM-240011_ref10","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3390\/medicina59081425","article-title":"Blood biomarkers of neonatal sepsis with special emphasis on the monocyte distribution width value as an early sepsis \u0131ndex","volume":"59","author":"Mubaraki","year":"2023","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"10.3233\/NPM-240011_ref11","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/21691401.2023.2252016","article-title":"Advancement in biomarker based effective diagnosis of neonatal sepsis","volume":"51","author":"Gopal","year":"2023","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"12","key":"10.3233\/NPM-240011_ref12","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1080\/14767058.2017.1322060","article-title":"Biomarkers for diagnosis of neonatal sepsis: A literature review","volume":"31","author":"Sharma","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"4","key":"10.3233\/NPM-240011_ref13","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s12098-011-0404-2","article-title":"Neonatal sepsis","volume":"78","author":"Wattal","year":"2011","journal-title":"Indian J Pediatr"},{"issue":"6","key":"10.3233\/NPM-240011_ref14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1055\/s-0038-1639361","article-title":"New diagnostic possibilities for neonatal sepsis","volume":"35","author":"Tzialla","year":"2018","journal-title":"Am J Perinatol"},{"issue":"7","key":"10.3233\/NPM-240011_ref15","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/s41372-019-0363-4","article-title":"Procalcitonin versus C-reactive protein: Review of kinetics and performance for diagnosis of neonatal sepsis","volume":"39","author":"Eschborn","year":"2019","journal-title":"J Perinatol"},{"issue":"1","key":"10.3233\/NPM-240011_ref16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12887-018-1236-2","article-title":"The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis","volume":"18","author":"Aydemir","year":"2018","journal-title":"BMC Pediatr"},{"key":"10.3233\/NPM-240011_ref17","doi-asserted-by":"crossref","unstructured":"Yorulmaz A , Y\u00fccel M , Sert S . Yenido\u011fan sepsis olgular\u0131nda hematolojik parametrelerin tan\u0131sal de\u011feri. 2018:252\u2013262.","DOI":"10.21601\/ortadogutipdergisi.389829"},{"issue":"23","key":"10.3233\/NPM-240011_ref18","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1080\/14767058.2018.1475643","article-title":"Comparison between presepsin and procalcitonin in early diagnosis of neonatal sepsis","volume":"32","author":"Iskandar","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"1","key":"10.3233\/NPM-240011_ref19","first-page":"1","article-title":"Yenido\u011fan sepsisinin erken tan\u0131s\u0131nda t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc-alfa\u2019n\u0131n rol\u00fc ve prognozla ili\u015fkisi","volume":"30","author":"\u015eahin","year":"2015","journal-title":"Medeni Med J"},{"issue":"4","key":"10.3233\/NPM-240011_ref20","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.pcl.2004.03.009","article-title":"Diagnosis and management of bacterial infections in the neonate","volume":"51","author":"Gerdes","year":"2004","journal-title":"Pediatr Clin North Am"},{"issue":"2","key":"10.3233\/NPM-240011_ref21","first-page":"142","article-title":"Neonatal sepsis","volume":"54","author":"Odabasi","year":"2020","journal-title":"Sisli Etfal Hastan Tip Bul"},{"issue":"4","key":"10.3233\/NPM-240011_ref22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF02002720","article-title":"Risk factors for nosocomial sepsis in newborn intensive and intermediate care units","volume":"155","author":"Moro","year":"1996","journal-title":"Eur J Pediatr"},{"issue":"6","key":"10.3233\/NPM-240011_ref23","doi-asserted-by":"crossref","first-page":"e0234472","DOI":"10.1371\/journal.pone.0234472","article-title":"Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study","volume":"15","author":"Akalu","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.3233\/NPM-240011_ref24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.pedneo.2015.09.007","article-title":"Early and late \u0131nfections in newborns: Where Do We Stand? A Review","volume":"57","author":"Cortese","year":"2016","journal-title":"Pediatr Neonatol"},{"issue":"3","key":"10.3233\/NPM-240011_ref25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1875-9572(09)60042-5","article-title":"Neonatal sepsis: A 6-year analysis in a neonatal care unit in Taiwan","volume":"50","author":"Wu","year":"2009","journal-title":"Pediatr Neonatol"},{"key":"10.3233\/NPM-240011_ref26","doi-asserted-by":"crossref","unstructured":"Hematyar M , Najibpour R , Bayesh S , Hojjat A , Farshad A . Assessing the role of clinical manifestations and laboratory findings in neonatal sepsis. Arch Pediatr Infect Dis. 2017;5(1).","DOI":"10.5812\/pedinfect.29985"},{"issue":"12","key":"10.3233\/NPM-240011_ref27","doi-asserted-by":"crossref","first-page":"e14686","DOI":"10.1097\/MD.0000000000014686","article-title":"Clinical features and antimicrobial susceptibility profiles of culture-proven neonatal sepsis in a tertiary children\u2019s hospital, 2013 to 2017.","volume":"98","author":"Li","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"10.3233\/NPM-240011_ref28","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/01.inf.0000068206.11303.dd","article-title":"Utility of complete blood count and blood culture screening to diagnose neonatal sepsis in the asymptomatic at risk newborn","volume":"22","author":"Ottolini","year":"2003","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"10.3233\/NPM-240011_ref29","first-page":"364","article-title":"C-reactive Protein (CRP) as a single biomarker for diagnosis of neonatal sepsis: A comprehensive meta-analysis","volume":"26","author":"Shabuj","year":"2017","journal-title":"Mymensingh Med J"},{"issue":"5","key":"10.3233\/NPM-240011_ref30","doi-asserted-by":"crossref","first-page":"R192","DOI":"10.1186\/cc9309","article-title":"Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit","volume":"14","author":"de Jager","year":"2010","journal-title":"Crit Care"},{"issue":"1","key":"10.3233\/NPM-240011_ref31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5798\/dicletip.534856","article-title":"Yenido\u011fan sepsisinde tam kan say\u0131m\u0131 parametrelerinin tan\u0131sal de\u011feri","volume":"46","author":"Akke\u00e7eci","year":"2019","journal-title":"Dicle Med J"},{"issue":"8","key":"10.3233\/NPM-240011_ref32","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/INF.0b013e31825691e4","article-title":"Use of the complete blood cell count in late-onset neonatal sepsis","volume":"31","author":"Hornik","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.3233\/NPM-240011_ref33","doi-asserted-by":"crossref","unstructured":"Shah J , Balasubramaniam T , Yang J , Shah PS . Leukopenia and Neutropenia at Birth and Sepsis in Preterm Neonates of <32 Weeks\u2019 Gestation. Am J Perinatol. 2020.","DOI":"10.1055\/s-0040-1721133"},{"key":"10.3233\/NPM-240011_ref34","first-page":"263","article-title":"Evaluation of acquired thrombocytopenia in neonatal intensive care unit","volume":"14","author":"Sever","year":"2018","journal-title":"Bak\u0131rk\u00f6y T\u0131p Dergisi"},{"issue":"2","key":"10.3233\/NPM-240011_ref35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1658-3876(09)50024-6","article-title":"Nosocomial sepsis-induced late onset thrombocytopenia in a neonatal tertiary care unit: A prospective study","volume":"2","author":"Charoo","year":"2009","journal-title":"Hematol Oncol Stem Cell Ther"},{"issue":"4.1","key":"10.3233\/NPM-240011_ref36","first-page":"757","article-title":"\u0130ncidence of thrombocytopenia and changes in various platelet parameters, in blood culture positive neonatal sepsis","volume":"3","author":"Bhat","year":"2015","journal-title":"Int J Pediatr"},{"issue":"7","key":"10.3233\/NPM-240011_ref37","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/MPH.0000000000001272","article-title":"Is MPV a Predictive Marker for Neonatal Sepsis? A Pilot Study","volume":"40","author":"Hanaganahalli","year":"2018","journal-title":"J Pediatr Hematol Oncol"},{"issue":"6","key":"10.3233\/NPM-240011_ref38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcla.21552","article-title":"Mean platelet volume in neonatal sepsis","volume":"26","author":"Oncel","year":"2012","journal-title":"J Clin Lab Anal"},{"issue":"32","key":"10.3233\/NPM-240011_ref39","doi-asserted-by":"crossref","first-page":"e21649","DOI":"10.1097\/MD.0000000000021649","article-title":"Diagnostic value of mean platelet volume for neonatal sepsis: A systematic review and meta-analysis","volume":"99","author":"Wang","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.3233\/NPM-240011_ref40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12879-020-4875-5","article-title":"Predictive model for bacterial late-onset neonatal sepsis in a tertiary care hospital in Thailand","volume":"20","author":"Husada","year":"2020","journal-title":"BMC Infect Dis"}],"container-title":["Journal of Neonatal-Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NPM-240011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:44:03Z","timestamp":1777614243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/NPM-240011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":40,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3233\/npm-240011","relation":{},"ISSN":["1934-5798","1878-4429"],"issn-type":[{"value":"1934-5798","type":"print"},{"value":"1878-4429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,15]]}}}