{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:42:25Z","timestamp":1791229345636,"version":"4.1.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neonatal-Perinatal Medicine"],"published-print":{"date-parts":[[2024,8,29]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Fetal inflammatory response syndrome (FIRS), the fetal equivalent of chorioamnionitis, is associated with poorer neonatal outcomes. FIRS is diagnosed through placental histology, namely by the identification of funisitis (inflammation of the umbilical cord) and chorionic vasculitis (inflammation of fetal vessels within the chorionic plate). The aim of this study was to identify and evaluate associations between FIRS and neonatal outcomes in preterm neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective cohort study at a level III neonatal intensive care unit (NICU), from January 1\n                      <jats:sup>st<\/jats:sup>\n                      2008 to December 31\n                      <jats:sup>st<\/jats:sup>\n                      2022, involving all inborn neonates with a gestational age below 30 weeks. We compared preterm neonates based on whether their placental histology described funisitis with chorionic vasculitis (FCV) or not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The study included 113 preterms, 27 (23.9%) of those had FCV and 86 (76.1%) did not. After adjusting to gestational age, prolonged rupture of membranes and preeclampsia, FCV was independently associated with the development of early-onset sepsis (OR\u200a=\u200a7.3, p\u200a=\u200a0.021) and cystic periventricular leukomalacia (OR\u200a=\u200a4.6, p\u200a=\u200a0.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The authors identified an association between FIRS and the development of early-onset sepsis and cystic periventricular leukomalacia, highlighting the importance of early detection and management of this condition in order to improve long-term neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/npm-240017","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T12:26:44Z","timestamp":1718713604000},"page":"575-582","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Fetal inflammatory response syndrome predicts early-onset sepsis and cystic periventricular leukomalacia in preterm neonates: A retrospective study"],"prefix":"10.1177","volume":"17","author":[{"given":"A.","family":"Assun\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fl\u00f4r-de-Lima","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Gynecology-Obstetrics and Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Moita","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ferreras","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Gynecology-Obstetrics and Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.663161"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.08.030"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208302"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016665"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004377"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.49"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1053862"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.784741"},{"key":"ref010","first-page":"11","author":"Villamor-Martinez E","year":"2020","journal-title":"Front Immunol"},{"key":"ref011","first-page":"1","author":"Fowler JR","year":"2022","journal-title":"Chorioamnionitis"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1899-0"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.11.1.18.25"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12895"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2011.03.009"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1702942"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1159\/000320170"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701580515"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.00063.x"},{"key":"ref020","unstructured":"VolpeJJ, InderT, DarrasB, de VriesL de, du PlessisA, NeilJ, et al. 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