{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:33:28Z","timestamp":1777890808691,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["NeuroRehabilitation: An International, Interdisciplinary Journal"],"published-print":{"date-parts":[[2014,6,26]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Spasticity can be a severe disabling disorder requiring high-dose injections of botulinum toxin type A (BoNT-A). Efficacy and safety of high BoNT-A doses in reducing multi-level spasticity of subjects with brain injury and cerebral palsy were investigated. Pain and functional outcome were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>High doses (up to 840 IU) of incobotulinumtoxinA were injected in adult subjects with severe spasticity of the upper and lower limbs due to brain injury (BI) and cerebral palsy (CP). The Modified Ashworth Scale, Visual Analogue scale, Glasgow Outcome Scale, Franchay Arm Test (FAT) and Barthel Scale were employed to assess spasticity, pain and functional outcome at baseline, and 4 and 16 weeks after BoNT-A injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-two (12 M, 10 F; mean age 38.1 \u00b1 13.7 years) subjects \u2013 16 subjects with BI and 6 with CP \u2013 were enrolled. Elbow, wrist, fingers and ankle muscles showed significant spasticity reduction after BoNT-A injections. The mean FAT score improved, but the benefit was not significant. Three (13.6%) subjects complained of mild adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>High-dose BoNT-A injections were effective and safe in reducing spasticity of BI and CP subjects. A significant reduction of the pain was also observed, but global functionality and arm dexterity were unchanged.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/nre-141052","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T18:13:54Z","timestamp":1575396834000},"page":"515-522","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["High doses of a new botulinum toxin type A (NT-201) in adult patients with severe spasticity following brain injury and cerebral palsy"],"prefix":"10.1177","volume":"34","author":[{"given":"Domenico","family":"Intiso","sequence":"first","affiliation":[{"name":"Neuro-Rehabilitation Unit, Scientific Institute, Hospital \u2018Casa Sollievo della Sofferenza\u2019, San Giovanni Rotondo (Foggia), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Simone","sequence":"additional","affiliation":[{"name":"Neuro-Rehabilitation Unit, Scientific Institute, Hospital \u2018Casa Sollievo della Sofferenza\u2019, San Giovanni Rotondo (Foggia), Italy"},{"name":"Foundation rehabilitation \u201cGli Angeli di P.Pio\u201d, San Giovanni Rotondo (Foggia), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Di Rienzo","sequence":"additional","affiliation":[{"name":"Neuro-Rehabilitation Unit, Scientific Institute, Hospital \u2018Casa Sollievo della Sofferenza\u2019, San Giovanni Rotondo (Foggia), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Iarossi","sequence":"additional","affiliation":[{"name":"Neuro-Rehabilitation Unit, Scientific Institute, Hospital \u2018Casa Sollievo della Sofferenza\u2019, San Giovanni Rotondo (Foggia), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Pazienza","sequence":"additional","affiliation":[{"name":"Neuro-Rehabilitation Unit, Scientific Institute, Hospital \u2018Casa Sollievo della Sofferenza\u2019, San Giovanni Rotondo (Foggia), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Santamato","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, \u201cOORR Hospital\u201d, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Maruzzi","sequence":"additional","affiliation":[{"name":"Neuro-Rehabilitation Unit, Scientific Institute, Hospital \u2018Casa Sollievo della Sofferenza\u2019, San Giovanni Rotondo (Foggia), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Basciani","sequence":"additional","affiliation":[{"name":"Neuro-Rehabilitation Unit, Scientific Institute, Hospital \u2018Casa Sollievo della Sofferenza\u2019, San Giovanni Rotondo (Foggia), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,6,26]]},"container-title":["NeuroRehabilitation: An International, Interdisciplinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NRE-141052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/NRE-141052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:46:27Z","timestamp":1777614387000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/NRE-141052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,26]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6,26]]}},"alternative-id":["10.3233\/NRE-141052"],"URL":"https:\/\/doi.org\/10.3233\/nre-141052","relation":{},"ISSN":["1053-8135","1878-6448"],"issn-type":[{"value":"1053-8135","type":"print"},{"value":"1878-6448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,26]]}}}