{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:46:15Z","timestamp":1777891575231,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NRE"],"published-print":{"date-parts":[[2021,4,30]]},"abstract":"<jats:p>BACKGROUND We have shown elevated levels of p53 and active caspase-3 in the heart with Parkinson disease (PD). The main aim of this study is to examine the effect of treadmill training on the cardiac expression of p53 and active caspase-3 in the mouse with induced Parkinsonism. METHODS: Thirty randomly selected normal albino mice were equally divided into the following 3 groups: sedentary control (SC), sedentary Parkinson diseased (SPD), and exercised Parkinson diseased (EPD). 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid (MPTP\/p) were used to induce chronic Parkinson disease in the SPD and EPD animals. The expression of p53 and active caspase-3 was investigated, using immunohistochemistry, in the heart in each animal group. RESULTS: Both p53 and active caspase-3 expression was significantly (p value\u200a&lt;\u200a0.05) reduced in the PD heart following endurance exercise training. CONCLUSION: Our present data suggest that chronic exercise training reduced PD-induced upregulation of p53 and active caspase-3 in the heart. Thus, our study suggests that inhibiting p53 and\/or active caspase-3 may be considered as a therapeutic approach to ameliorate PD cardiomyopathy.<\/jats:p>","DOI":"10.3233\/nre-201650","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T14:58:36Z","timestamp":1617116316000},"page":"315-320","source":"Crossref","is-referenced-by-count":3,"title":["Endurance exercise training suppresses Parkinson disease-induced overexpression of apoptotic mediators in the heart"],"prefix":"10.1177","volume":"48","author":[{"given":"Muhammed D.","family":"Al-Jarrah","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour S.","family":"Erekat","sequence":"additional","affiliation":[{"name":"Department of Anatomy. 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