{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:18:32Z","timestamp":1778703512198,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NRE"],"published-print":{"date-parts":[[2021,6,16]]},"abstract":"<jats:p>BACKGROUND: Patients with cerebral palsy and other static encephalopathies (CP) are known to be at increased risk of sleep-related breathing disorders (SRBD). Few studies have reviewed whether intrathecal baclofen (ITB) can contribute to SRBD. OBJECTIVE: To assess the prevalence of SRBD in patients with CP receiving ITB by using nocturnal polysomnography (NPSG). METHODS: We performed a retrospective chart review of patients receiving ITB who had NPSG at Children\u2019s Hospital Colorado (CHCO) and Seattle Children\u2019s Hospital (SCH) from 1995 to 2019. The Gross Motor Function Classification System (GMFCS) measured the severity of motor disability. Screening sleep questionnaires collected subjective data and NPSG provided objective data of SRBD. RESULTS: All patients except one were GMFCS 4 or 5 with median age at ITB pump placement of 9.7 years. The screening questionnaire for SRBD detected one or more nighttime symptoms in\u200a&gt;\u200a82% of all patient groups. Pre-ITB criteria for a SRBD was met in 83% of patients at CHCO and 91% at SCH. Post-ITB prevalence remained similarly high. CONCLUSIONS: NPSG identified a high prevalence of SRBD in these cohorts from CHCO and SCH. Our study showed neither improvement nor worsening of SRBD in patients receiving ITB.<\/jats:p>","DOI":"10.3233\/nre-210012","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T05:44:26Z","timestamp":1620193466000},"page":"481-491","source":"Crossref","is-referenced-by-count":3,"title":["Sleep-related breathing disorders associated with intrathecal baclofen therapy to treat patients with cerebral palsy: A cohort study and discussion"],"prefix":"10.1177","volume":"48","author":[{"given":"Ricky T.","family":"Mohon","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital Colorado and Division of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Colorado, Department of Rehabilitation, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaci","family":"Pickett","sequence":"additional","affiliation":[{"name":"Colorado School of Public Health, Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Bothwell","sequence":"additional","affiliation":[{"name":"Colorado School of Public Health, Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Brinton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Sobremonte-King","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital and Division of Pulmonary and Sleep Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes M.","family":"DelRosso","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital and Division of Pulmonary and Sleep Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"5","key":"10.3233\/NRE-210012_ref1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/00006123-199605000-00015","article-title":"Continuous intrathecal baclofen infusion for symptomatic generalized dystonia","volume":"38","author":"Albright,","year":"1996","journal-title":"Neurosurgery"},{"key":"10.3233\/NRE-210012_ref2","unstructured":"American Academy of Sleep Medicine. 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