{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:31:56Z","timestamp":1789767116356,"version":"4.0.1"},"reference-count":73,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NRE"],"published-print":{"date-parts":[[2022,1,31]]},"abstract":"<jats:p>BACKGROUND: Increasing evidence suggests autonomic nervous system (ANS) dysfunction may occur following mild traumatic brain injury (mTBI). Measures of heart rate, heart rate variability, blood pressure and baroreceptor sensitivity can be used to evaluate ANS dysfunction following mTBI. OBJECTIVE: Summarize the evidence for ANS dysfunction in adults following mTBI. METHODS: A search of Embase, MEDLINE, Cochrane Central Register, PsycINFO, CINAHL and SPORTDiscus databases was conducted. Search topics included: mTBI and ANS. Identified abstracts were independently reviewed by 2 reviewers followed by full text screening. Risk of bias was assessed using a modified SIGN checklist. A structured synthesis was performed. RESULTS: Thirty-nine studies (combined 1,467 participants diagnosed with mTBI) evaluating ANS function were included. ANS function was evaluated under various conditions including: rest, during exertion, cold pressor test, Valsalva maneuver, using face cooling and eyeball pressure paradigms. Short-term or ultra-short-term recordings were most common. The majority of studies (28\/39) were rated as \u201cunacceptable\u201d for quality of evidence. CONCLUSIONS: Altered parameters of ANS function have been reported in multiple conditions following mTBI, both acutely and in the post-acute\/chronic stages of recovery. However, due to methodological limitations, conclusions regarding the severity and timing of ANS dysfunction following mTBI cannot be drawn.<\/jats:p>","DOI":"10.3233\/nre-210243","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T12:38:09Z","timestamp":1642768689000},"page":"3-32","source":"Crossref","is-referenced-by-count":43,"title":["Autonomic dysfunction in adults following mild traumatic brain injury: A systematic review"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-6572","authenticated-orcid":false,"given":"Leah J.","family":"Mercier","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Physical Medicine and Rehabilitation, University of Caglary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Batycky","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Physical Medicine and Rehabilitation, University of Caglary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Physical Medicine and Rehabilitation, University of Caglary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Schneider","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada"},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Sport Medicine Centre, Faculty of Kinesiology, University of Calgary, Calgary, AB, 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