{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:18:16Z","timestamp":1790705896366,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NRE"],"published-print":{"date-parts":[[2023,2,23]]},"abstract":"<jats:p>BACKGROUND: Mild traumatic brain injury (mTBI) treatment research is hindered by lack of clinically meaningful and responsive outcome measures. One promising measure is the World Health Organisation Disability Assessment Schedule 2.0 (WHODAS 2.0), although minimal clinically important differences (MCID) for have not been established. OBJECTIVE: To estimate MCID for the WHODAS 2.0 for mTBI. METHODS: We analysed two prospectively collected mTBI datasets (n\u200a=\u200a225) attending adult outpatient clinics in British Columbia, Canada. Participants completed the 12-item WHODAS 2.0, Patient Global Impression of Change scale, and Rivermead Post-Concussion Symptoms Questionnaire. We used anchor- and distribution-based methods to explore MCIDs in WHODAS 2.0 scores. RESULTS: For Study 1 (n\u200a=\u200a131), the anchor and distribution-based approaches produced minimal change estimates ranging from 1.3 to 2.8 interval scores. For Study 2 (n\u200a=\u200a94), the anchor and distribution-based approaches produced minimal change estimates from 2.2 to 3.2 interval scores. For certain subgroups based on age, sex, and post-concussion severity, minimal change estimates were slightly higher. CONCLUSION: An MCID of 3.5 interval WHODAS 2.0 points would conservatively capture meaningful change in adults of varying age, sex, and post-concussion symptom severity. Such a uniform metric will assist future mTBI intervention studies to improve standards of care and evaluation of outcomes.<\/jats:p>","DOI":"10.3233\/nre-220004","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T05:41:51Z","timestamp":1671860511000},"page":"249-257","source":"Crossref","is-referenced-by-count":10,"title":["Derivation of a minimal clinically important difference score for the WHODAS 2.0 in mild traumatic brain injury"],"prefix":"10.1177","volume":"52","author":[{"given":"Deborah L.","family":"Snell","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago Christchurch, Christchurch, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah D.","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/NRE-220004_ref1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1089\/neu.2014.3495","article-title":"Comparative Study of Outcome Measures and Analysis Methods for Traumatic Brain Injury Trials","volume":"32","author":"Alali,","year":"2015","journal-title":"Journal of Neurotrauma"},{"issue":"9","key":"10.3233\/NRE-220004_ref2","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1080\/02699052.2020.1797168","article-title":"Treatment outcomes in mild traumatic brain injury: a systematic review of randomized controlled trials","volume":"34","author":"Arbabi,","year":"2020","journal-title":"Brain Injury"},{"key":"10.3233\/NRE-220004_ref3","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.2196\/mental.7497","article-title":"The 12-item self-report World Health Organization Disability Assessment Schedule (WHODAS). 2.0 administered via the Internet to individuals with anxiety and stress disorders: a psychometric investigation based on data from two clinical trials","volume":"4","author":"Axelsson,","year":"2017","journal-title":"JMIR Mental Health"},{"issue":"3","key":"10.3233\/NRE-220004_ref4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/0272989X05276863","article-title":"Sufficiently Important Difference: Expanding the Framework of Clinical Significance","volume":"25","author":"Barrett,","year":"2005","journal-title":"Medical Decision Making"},{"issue":"4","key":"10.3233\/NRE-220004_ref6","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1089\/neu.2018.5873","article-title":"Outcomes after Concussion Recovery Education: Effects of Litigation and Disability Status on Maintenance of Symptoms","volume":"36","author":"Hanks,","year":"2019","journal-title":"Journal of Neurotrauma"},{"issue":"3","key":"10.3233\/NRE-220004_ref7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1080\/16501970510027321","article-title":"Summary of the WHO Collaborating Centre for Neurotrauma Task Force on Mild Traumatic Brain Injury","volume":"37","author":"Holm,","year":"2005","journal-title":"Journal of Rehabilitation Medicine"},{"key":"10.3233\/NRE-220004_ref8","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1089\/neu.2018.5648","article-title":"Randomized Controlled Trials in Adult Traumatic Brain Injury: A Systematic Review on the Use and Reporting of Clinical Outcome Assessments","volume":"35","author":"Horton,","year":"2018","journal-title":"Journal of Neurotrauma"},{"key":"10.3233\/NRE-220004_ref9","first-page":"407","article-title":"Measurement of health status. 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