{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:46:42Z","timestamp":1777891602541,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NRE"],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:p>BACKGROUND: Osteoporotic vertebral fractures (OVFs) are often followed by chronic back pain which may have a nociceptive, neuropathic, or mixed component. However, literature on this topic is lacking. OBJECTIVE: The objective of this cross-sectional study is to characterize the neuropathic component of chronic back pain in patients with OVFs. METHODS: Spine fractures were detected by morphometric examination. Pain severity and its impact on activities of daily living (ADL) were evaluated through the Brief Pain Inventory (BPI). Neuropathic pain was investigated through the Italian versions of the Leeds Assessment of Neuropathic Symptoms and Signs pain scale (LANSS) and the painDETECT questionnaire (PD-Q). RESULTS: We included 72 patients, mainly women (88.8%), with mean age of 69.2 years. The 70.8% of patients had multiple OVFs, of which 47% located at the thoracic spine, 43.1% at the thoracic and at lumbar spine, and 9.8% at the lumbar spine. The BPI showed moderate back pain in 23.6% of cases and severe in 8.3% of cases, with high interference with ADL in 38.9% of patients. The PD-Q revealed the presence of neuropathic pain in 5.5% of cases, while the LANSS in 23.6% of cases. CONCLUSIONS: In our study, the prevalence of neuropathic component of chronic back pain ranged from 5.5% to 23.6%, according to PD-Q and LANSS respectively, in patients with OVFs. Further studies should investigate if the characterization of chronic back pain might contribute to appropriateness of interventions for this population.<\/jats:p>","DOI":"10.3233\/nre-220040","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T11:57:57Z","timestamp":1653047877000},"page":"325-331","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of neuropathic component of back pain in patients with osteoporotic vertebral fractures"],"prefix":"10.1177","volume":"51","author":[{"given":"Antimo","family":"Moretti","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Specialties and Dentistry, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Liguori","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties and Dentistry, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Paoletta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties and Dentistry, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Toro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties and Dentistry, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Aulicino","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties and Dentistry, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Gimigliano","sequence":"additional","affiliation":[{"name":"Department of Mental, Physical Health and Preventive Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Iolascon","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties and Dentistry, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"1","key":"10.3233\/NRE-220040_ref1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4184\/jkss.2017.24.1.59","article-title":"Analgesic Effects of Antiosteoporotic Drugs","volume":"24","author":"Ahn,","year":"2017","journal-title":"Journal of Korean Society of Spine Surgery"},{"key":"10.3233\/NRE-220040_ref2","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1359\/jbmr.1999.14.6.960","article-title":"Intermittent parathyroid hormone (1\u201334) treatment increases callus formation and mechanical strength of healing rat fractures","volume":"14","author":"Andreassen,","year":"1999","journal-title":"J Bone Miner Res"},{"issue":"6","key":"10.3233\/NRE-220040_ref3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00002517-199812000-00013","article-title":"Innervation of the human vertebral body: a histologic study","volume":"11","author":"Antonacci,","year":"1998","journal-title":"Journal of Spinal Disorders"},{"issue":"6","key":"10.3233\/NRE-220040_ref4","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/ejp.838","article-title":"Neuropathic low back pain in clinical practice","volume":"20","author":"Baron,","year":"2016","journal-title":"European Journal of Pain (London, England)"},{"issue":"1","key":"10.3233\/NRE-220040_ref5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(95)00156-5","article-title":"A validation study of an Italian version of the Brief Pain Inventory (Breve Questionario per la Valutazione del Dolore)","volume":"65","author":"Caraceni,","year":"1996","journal-title":"Pain"},{"issue":"1","key":"10.3233\/NRE-220040_ref6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.17712\/nsj.2018.1.20170345","article-title":"Comparison of 2 methods of neuropathic pain assessment in carpal tunnel syndrome and hand functions","volume":"23","author":"Ceceli,","year":"2018","journal-title":"Neurosciences (Riyadh, Saudi Arabia)"},{"issue":"2","key":"10.3233\/NRE-220040_ref7","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory. 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