{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:12:36Z","timestamp":1792037556259,"version":"4.4.0"},"reference-count":101,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["NeuroRehabilitation"],"published-print":{"date-parts":[[2023,4,11]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Brain-derived neurotrophic factor (BDNF) promotes activity-dependent neuroplasticity and is released following aerobic-exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>Feasibility and efficacy of 1.Moderate-Intensity Cycle-Ergometer-Training (MI-ET) and 2.Low-Intensity Circuit-Training (LI-CT) on BDNF-serum-concentration in chronic-stroke and consequently efficacy of motor-learning in varying BDNF-concentrations (neuroplasticity being the substrate for motor-learning) via upper-limb robotic-training (RT) in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Randomised-control feasibility-study. 12-week, 3x\/week intervention, 17 chronic-stroke-survivors randomized into: (1) MI-ET&amp;RT or (2) LI-CT&amp;RT. Both groups completed 40\u200amins MI-ET or LI-CT followed by 40\u200amins RT. Feasibility outcomes: (1) screening and enrollment-rates, (2) retention-rates, (3) adherence: (i) attendance-rates, (ii) training-duration, (4) adverse events. Primary clinical outcomes: 1. serum-BDNF changes pre-post training (immediate) and pre-training basal-levels over 12-weeks (long-term). 2.upper-limb performance with Action-Research-Arm-Test (ARAT). Additionally, feasibility of an embedded health economic evaluation (HEE) to evaluate health-costs and cost-effectiveness. Outcomes: cost-questionnaire return-rates, cost-of-illness (COI) and Health-Utitility-Index (HUI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>21.5% of eligible and contactable enrolled. 10 randomized to MI-ET and 7 to LI-CT. 85% of training-sessions were completed in MI-ET (306\/360) and 76.3% in LI-CT-group (165\/216). 12-weeks: Drop-outs MI-ET-10%, LI-CT-43%. Clinical outcomes: No significant changes in immediate or long-term serum-BDNF in either group. Moderate-intensity aerobic-training did not increase serum-BDNF post-stroke. Individual but no group clinically-relevant changes in ARAT-scores. HEE outcomes at 12-weeks: 100% cost-questionnaires returned. Group-costs baseline and after treatment, consistently favouring MI-ET group. COI: (1-year-time-frame): MI-ET 67382 SD (43107) Swiss-Francs and LI-CT 95701(29473) Swiss-Francs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The study is feasible with modifications. Future studies should compare high-intensity versus moderate-intensity aerobic-exercise combined with higher dosage arm-training.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/nre-220239","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T11:54:17Z","timestamp":1676634857000},"page":"485-506","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of moderate-intensity aerobic exercise on serum BDNF and motor learning in the upper-limb in patients after chronic-stroke: A randomized, controlled feasibility study with embedded health economic evaluation"],"prefix":"10.1177","volume":"52","author":[{"given":"Clare","family":"Maguire","sequence":"first","affiliation":[{"name":"Clinic for Neurorehabilitation and Paraplegiology","place":["Switzerland"]},{"name":"Bern University of Applied Science","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Betschart","sequence":"additional","affiliation":[{"name":"Clinic for Neurorehabilitation and Paraplegiology","place":["Switzerland"]},{"name":"Bern University of Applied Science","place":["Switzerland"]},{"name":"Kantonal Hospital Winterthur","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Pohl","sequence":"additional","affiliation":[{"name":"University Hospital Zurich","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Primani","sequence":"additional","affiliation":[{"name":"Clinic for Neurorehabilitation and Paraplegiology","place":["Switzerland"]},{"name":"Bern University of Applied Science","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Taeymans","sequence":"additional","affiliation":[{"name":"Bern University of Applied Science","place":["Switzerland"]},{"name":"Vrije Universiteit Brussel","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margret","family":"Hund-Georgiadis","sequence":"additional","affiliation":[{"name":"Clinic for Neurorehabilitation and Paraplegiology","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-193013"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.01202.x"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215515606197"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000022"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0519-8"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000537"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-9514(14)60111-2"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/1650197719702239298"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00594.2018"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1310\/tsr2103-246"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24472"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-015-1196-z"},{"key":"e_1_3_4_14_1","doi-asserted-by":"crossref","unstructured":"Conroy S. 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