{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:15:04Z","timestamp":1790759704479,"version":"4.1.0"},"reference-count":107,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NRE"],"published-print":{"date-parts":[[2024,1,23]]},"abstract":"<jats:p>Disorders of consciousness after severe brain injury encompass conditions of coma, vegetative state\/unresponsive wakefulness syndrome, and minimally conscious state. DoC clinical presentation pose perplexing challenges to medical professionals, researchers, and families alike. The outcome is uncertain in the first weeks to months after a brain injury, with families and medical providers often making important decisions that require certainty. Prognostication for individuals with these conditions has been the subject of intense scientific investigation that continues to strive for valid prognostic indicators and algorithms for predicting recovery of consciousness. This manuscript aims to provide an overview of the current clinical landscape surrounding prognosis and optimizing recovery in DoC and the current and future research that could improve prognostic accuracy after severe brain injury. Improved understanding of these factors will aid healthcare professionals in providing optimal care, fostering hope, and advocating for ethical practices in the management of individuals with DoC.<\/jats:p>","DOI":"10.3233\/nre-230148","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T13:42:04Z","timestamp":1706017324000},"page":"43-59","source":"Crossref","is-referenced-by-count":8,"title":["Prognosis and enhancement of recovery in disorders of consciousness"],"prefix":"10.1177","volume":"54","author":[{"given":"Mary E.","family":"Russell","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Texas McGovern Medical School, Houston, TX, USA"},{"name":"TIRR Memorial Hermann - The Woodlands, Shenandoah, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora M.","family":"Hammond","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Rehabilitation Hospital of Indiana, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Murtaugh","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Programs, Madonna Rehabilitation Hospitals, Lincoln, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/NRE-230148_ref1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.expneurol.2015.02.011","article-title":"White matter involvement after TBI: Clues to axon and myelin repair capacity","volume":"275 Pt 3","author":"Armstrong,","year":"2016","journal-title":"Experimental Neurology"},{"issue":"20","key":"10.3233\/NRE-230148_ref2","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1089\/neu.2020.7129","article-title":"The Dilemma of Hydrocephalus in Prolonged Disorders of Consciousness","volume":"37","author":"Arnts,","year":"2020","journal-title":"Journal of Neurotrauma"},{"issue":"2","key":"10.3233\/NRE-230148_ref3","first-page":"97","article-title":"Epidemiological and clinical characteristics of patients in a vegetative state in Italian rehabilitation units. 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