{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:47:55Z","timestamp":1777891675618,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NRE"],"published-print":{"date-parts":[[2024,11,6]]},"abstract":"<jats:p>BACKGROUND: Conducting mild traumatic brain injury (mTBI) longitudinal studies across multiple sites is a challenging endeavor which has been made more challenging because of COVID-19. OBJECTIVE: This article briefly describes several concerns that need to be addressed during the conduct of research to account for COVID-19\u2019s impact. METHODS: The recent actions and steps taken by the Long-term Impact of Military-relevant Brain Injury Consortium (LIMBIC)-Chronic Effects of Neurotrauma Consortium (CENC) researchers are reviewed. RESULTS: COVID-19\u2019s effects on the conduct of LIMBIC-CENC for the short-term and long-term were considered to ensure the study continued safely for participants and researchers. COVID-19 may have long-lasting health and especially neurological effects which may confound the quantitative and qualitative measures of this any comparable longitudinal studies. CONCLUSION: The recognition, understanding, and preparation of COVID-19\u2019s impact on a longitudinal military and veteran mTBI population is crucial to successfully conducting LIMBIC-CENC and similar neurological research studies. Developing a plan based on the best available information while remaining agile as new information about COVID-19 emerge, is essential. Research presented in this special issue underscores the complexity of studying long-term effects of mTBI, in a population exposed to and symptomatic from COVID-19.<\/jats:p>","DOI":"10.3233\/nre-230272","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T10:53:39Z","timestamp":1720781619000},"page":"369-374","source":"Crossref","is-referenced-by-count":0,"title":["LIMBIC-CENC: Successfully conducting longitudinal mTBI research during the COVID-19 pandemic"],"prefix":"10.1177","volume":"55","author":[{"given":"Sidney R.","family":"Hinds II","sequence":"first","affiliation":[{"name":"Uniformed Services University, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David X.","family":"Cifu","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"5","key":"10.3233\/NRE-230272_ref1","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1007\/s00415-021-10848-4","article-title":"Acute and post-acute neurological manifestations of COVID-19: present findings, critical appraisal, and future directions","volume":"269","author":"Beghi,","year":"2022","journal-title":"J Neurol"},{"issue":"5","key":"10.3233\/NRE-230272_ref2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/02699052.2022.2033843","article-title":"Clinical research findings from the long-term impact of military-relevant brain injury consortium-Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC) 2013\u20132021","volume":"36","author":"Cifu,","year":"2022","journal-title":"Brain Inj"},{"issue":"9","key":"10.3233\/NRE-230272_ref3","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s00415-021-10406-y","article-title":"Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19)","volume":"268","author":"Harapan,","year":"2021","journal-title":"J Neurol"},{"issue":"6","key":"10.3233\/NRE-230272_ref4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.tcm.2022.04.004","article-title":"COVID-19 and the brain","volume":"32","author":"Hingorani,","year":"2022","journal-title":"Trends Cardiovasc Med"},{"issue":"7","key":"10.3233\/NRE-230272_ref5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/PHM.0000000000001460","article-title":"The War on COVID-19 Pandemic: Role of Rehabilitation Professionals and Hospitals","volume":"99","author":"Lew,","year":"2020","journal-title":"Am J Phys Med Rehabil"},{"key":"10.3233\/NRE-230272_ref6","doi-asserted-by":"crossref","unstructured":"Orban, Z. S. , Visvabharathy, L. , Perez Giraldo, G. S. , Jimenez, M. , Koralnik, I. J. (2023). SARS-CoV-2-Specific Immune Responses in Patients With Postviral Syndrome After Suspected COVID-19. Neurol Neuroimmunol Neuroinflamm, 10(6). https:\/\/doi.org\/10.1212\/nxi.0000000000200159.","DOI":"10.1212\/NXI.0000000000200159"},{"issue":"12","key":"10.3233\/NRE-230272_ref7","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1080\/02699052.2016.1219061","article-title":"The Chronic Effects of Neurotrauma Consortium (CENC) multi-centre observational study: Description of study and characteristics of early participants","volume":"30","author":"Walker,","year":"2016","journal-title":"Brain Inj"}],"container-title":["NeuroRehabilitation"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/NRE-230272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:08:42Z","timestamp":1777615722000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/NRE-230272"}},"subtitle":[],"editor":[{"given":"David X.","family":"Cifu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Sidney R.","family":"Hinds","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":7,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/nre-230272","relation":{},"ISSN":["1053-8135","1878-6448"],"issn-type":[{"value":"1053-8135","type":"print"},{"value":"1878-6448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,6]]}}}