{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:30:17Z","timestamp":1793374217154,"version":"4.5.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NRE"],"published-print":{"date-parts":[[2024,4,24]]},"abstract":"<jats:p>BACKGROUND: Patients with prolonged disorders of consciousness (pDOC) pose significant challenges to healthcare workers due to their severe motor impairments and limited interaction with the environment. Non-invasive brain stimulation such as high-definition transcranial direct current stimulation (HD-tDCS) and music stimulation show promise in awakening this population. OBJECTIVE: In this study, we present a protocol aiming at investigating the efficacy of combined HD-tDCS and music stimulation in awakening patients with pDOC through a single-blind, randomized controlled trial. METHODS: Ninety patients with pDOC will be randomly divided into three groups: active HD-tDCS with music stimulation, active HD-tDCS, and sham HD-tDCS. All participants will receive 20 treatment sessions over a period of 10 days and the Coma Recovery Scale-Revised, Glasgow Outcome Scale and electroencephalogram will be used as assessment measures to evaluate their level of consciousness throughout the study. Adverse events and complications will be recorded during treatment. Within-group pre-post comparisons and between-group efficacy comparisons will be conducted to identify the most effective intervention approach. Statistical analysis will be performed using SPSS software with a significance level set at P\u200a&lt;\u200a0.05. CONCLUSION: The pursuit of awakening therapy for patients with pDOC remains a clinical research challenge. This study protocol is designed with the aim of introducing an innovative non-pharmacological approach which combined HD-tDCS and music stimulation to facilitate the reinstatement of consciousness in patients with pDOC.<\/jats:p>","DOI":"10.3233\/nre-230282","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T11:54:03Z","timestamp":1709639643000},"page":"495-504","source":"Crossref","is-referenced-by-count":6,"title":["Combining HD-tDCS with music stimulation for patients with prolonged disorders of consciousness: Study protocol for an RCT trial"],"prefix":"10.1177","volume":"54","author":[{"given":"Jie","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, China"},{"name":"Department of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fubing","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingpu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, China"},{"name":"Department of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianrui","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Nan\u2019ao People\u2019s Hospital of Shenzhen, Dapeng New District, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Haikou Hospital Affiliated to Xiangya Medical College of Central South University, Haikou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/NRE-230282_ref1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/WNP.0000000000000538","article-title":"Overview of EEG Montages and Principles of Localization","volume":"36","author":"Acharya,","year":"2019","journal-title":"Journal of Clinical Neurophysiology: Official Publication of the 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