{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:47:39Z","timestamp":1777888059749,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Rehabilitation Medicine"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>PURPOSE: Low magnitude mechanical stimulation (LMMS) has been used\n\t\t\t successfully to promote bone formation in certain patient populations. This\n\t\t\t study evaluated the feasibility and effectiveness of LMMS on improving bone\n\t\t\t mineral density (BMD) in patients with Rett syndrome.<\/jats:p>\n                  <jats:p>METHODS: A 12-month crossover pilot study design of 6 months of\n\t\t\t intervention with LMMS and 6 months without was studied in 14 subjects divided\n\t\t\t in two subgroups. BMD was assessed using Dual Energy X-ray Absorptiometry\n\t\t\t (DXA). The levels of 25-hydroxy vitamin D (25OHD), Parathyroid Hormone (PTH),\n\t\t\t Insulin-Like Growth Factor 1 (IGF-1), and circulating markers of bone\n\t\t\t resorption (NTx) were analyzed in blood samples. Health questionnaires and diet\n\t\t\t logs were obtained at 0, 6, and 12 months.<\/jats:p>\n                  <jats:p>RESULTS: Of the 11 subjects who completed the protocol, 9 had an\n\t\t\t adherence of &gt; 65% and showed an increase in spine BMD Z-scores from the\n\t\t\t intervention (Z: \u22122.51) compared to non-intervention period (Z:\n\t\t\t \u22122.27) of 0.23 SD (p=0.048). Following intervention, favorable trends\n\t\t\t were also observed for IGF-1 (p=0.06) and right distal femur BMD Z-scores\n\t\t\t (p=0.07).<\/jats:p>\n                  <jats:p>CONCLUSIONS: These preliminary results are promising for a larger,\n\t\t\t placebo-controlled randomized study of subjects with Rett syndrome.<\/jats:p>","DOI":"10.3233\/prm-140286","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T17:13:26Z","timestamp":1575393206000},"page":"167-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of low magnitude mechanical stimulation (LMMS) on bone\t\t\t density in patients with Rett syndrome: A pilot and feasibility study"],"prefix":"10.1177","volume":"7","author":[{"given":"Sarah Y.","family":"Afzal","sequence":"first","affiliation":[{"name":"Katie's Clinic for Rett Syndrome, Children's Hospital\r\t\t\t &amp; Research Center Oakland, Oakland, CA, USA"},{"name":"Children's Hospital Oakland Research Institute,\r\t\t\t Oakland, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna R.","family":"Wender","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute,\r\t\t\t Oakland, CA, USA"},{"name":"Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary D.","family":"Jones","sequence":"additional","affiliation":[{"name":"Katie's Clinic for Rett Syndrome, Children's Hospital\r\t\t\t &amp; Research Center Oakland, Oakland, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen B.","family":"Fung","sequence":"additional","affiliation":[{"name":"HEDCO Health Sciences Center, Children's Hospital\r\t\t\t Oakland Research Institute, Oakland, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine L.","family":"Pico","sequence":"additional","affiliation":[{"name":"Katie's Clinic for Rett Syndrome, Children's Hospital\r\t\t\t &amp; Research Center Oakland, Oakland, CA, USA"},{"name":"Children's Hospital Oakland Research Institute,\r\t\t\t Oakland, CA, USA"},{"name":"Division of Pediatric and Rehabilitative Medicine,\r\t\t\t Children's Hospital &amp; Research Center Oakland, Oakland, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1]]},"container-title":["Journal of Pediatric Rehabilitation Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/PRM-140286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/PRM-140286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:33:54Z","timestamp":1777610034000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/PRM-140286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.3233\/PRM-140286"],"URL":"https:\/\/doi.org\/10.3233\/prm-140286","relation":{},"ISSN":["1874-5393","1875-8894"],"issn-type":[{"value":"1874-5393","type":"print"},{"value":"1875-8894","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}