{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:17Z","timestamp":1791309857857,"version":"4.3.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PRM"],"published-print":{"date-parts":[[2023,4,6]]},"abstract":"<jats:p>PURPOSE: Cerebral palsy is a common pediatric neurological problem that has multiple comorbidities, including nutritional issues. Hematological and biochemical parameters significantly affect the health status of patients with cerebral palsy, and till now very few studies have analyzed these parameters. This study aimed to describe the hematological and biochemical parameters of children diagnosed with cerebral palsy. METHODS: This four-year observational study included children with cerebral palsy who were admitted to the Department of Pediatrics of a medical college teaching hospital. Hemoglobin, platelet count, white blood count (WBC), red blood cells (RBCs), packed cell volume, RBC indices, and biochemical parameters (urea, creatinine, total bilirubin, total protein, albumin, globulin, aspartate transaminase, alanine transaminase, electrolytes, calcium and alkaline phosphatase) were noted and values (mean, standard deviation, and interquartile range) presented. Age and gender-based analyses were performed. RESULTS: The average hemoglobin level was 11.48\u200amg\/dl, platelet count was 301.24\u00d7109\/L, and WBC count was 11.13 109\/L. Anemia was observed more commonly in males younger than nine years of age. Of 282 patients, 14 (4.96%) had a platelet count of less than 150\u00d7109\/L. Abnormal alkaline phosphatase levels were observed more commonly in patients who were younger than nine years of age and in females more than males, and the difference was statistically significant. Protein levels and calcium levels were similar between both age groups. CONCLUSION: Anemia was more common in younger patients and males with cerebral palsy. Abnormal bone turnover markers (alkaline phosphatase) were more common in young patients and females with cerebral palsy. Understanding the differential effect of age and gender on various investigational parameters will help improve care of children with cerebral palsy by initiating appropriate and timely clinical interventions, thereby providing a better quality of life.<\/jats:p>","DOI":"10.3233\/prm-201514","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T12:15:01Z","timestamp":1678796101000},"page":"171-177","source":"Crossref","is-referenced-by-count":5,"title":["Hematological and biochemical profiles in children with cerebral palsy: A cross-sectional study"],"prefix":"10.1177","volume":"16","author":[{"given":"Rohit","family":"Khandelwal","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Vankalapati","family":"Manjunath","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leeni","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Apollo Group of Hospitals, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivalingappa Bussenahalli","family":"Mangajjera","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"10","key":"10.3233\/PRM-201514_ref1","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.3390\/jcm8101599","article-title":"Early diagnosis and classification of cerebral palsy: An historical perspective and barriers to an early diagnosis","volume":"8","author":"Velde te","year":"2019","journal-title":"J Clin Med"},{"issue":"4","key":"10.3233\/PRM-201514_ref2","doi-asserted-by":"publisher","first-page":"e0124120","DOI":"10.1371\/journal.pone.0124120","article-title":"Trends in the prevalence of autism spectrum disorder, cerebral palsy, hearing loss, intellectual disability, and vision impairment, metropolitan Atlanta","volume":"10","author":"Van Naarden Braun","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"10.3233\/PRM-201514_ref3","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1111\/j.1651-2227.2010.01819.x","article-title":"The changing panorama of cerebral palsy in Sweden","volume":"99","author":"Himmelmann","year":"2010","journal-title":"X. Prevalence and origin in the birth-year period 1999\u20132002 Acta Paediatr"},{"issue":"3","key":"10.3233\/PRM-201514_ref4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1179\/146532810X12786388978481","article-title":"A review of the incidence and prevalence, types and aetiology of childhood cerebral palsy in resource-poor settings","volume":"30","author":"Gladstone","year":"2010","journal-title":"Ann Trop Paediatr"},{"issue":"6","key":"10.3233\/PRM-201514_ref5","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1093\/tropej\/fmt035","article-title":"Changes in the clinical spectrum of cerebral palsy over two decades in North India\u2013an analysis of cases","volume":"59","author":"Singhi","year":"2013","journal-title":"J Trop Pediatr"},{"issue":"5","key":"10.3233\/PRM-201514_ref6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s13312-014-0414-z","article-title":"Health-related quality of life in children with cerebral palsy and their families","volume":"51","author":"Dobhal","year":"2014","journal-title":"Indian Pediatr"},{"issue":"4","key":"10.3233\/PRM-201514_ref7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1590\/S0004-2803.201800000-78","article-title":"Food intake, nutritional status and gastrointestinal symptoms in children with cerebral palsy","volume":"55","author":"Caramico-Favero","year":"2018","journal-title":"Arq Gastroenterol"},{"issue":"1","key":"10.3233\/PRM-201514_ref8","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1186\/s12883-019-1553-6","article-title":"Malnutrition is common in children with cerebral palsy in Saudi Arabia - A cross- sectional clinical observational study","volume":"19","author":"Almuneef","year":"2019","journal-title":"BMC Neurol"},{"issue":"1","key":"10.3233\/PRM-201514_ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3944\/AOTT.2011.2472","article-title":"Preoperative hematological assessment of pediatric patients with cerebral palsy","volume":"45","author":"Omero\u011flu","year":"2011","journal-title":"Acta Orthop Traumatol Turc"},{"issue":"4","key":"10.3233\/PRM-201514_ref10","doi-asserted-by":"publisher","first-page":"387","DOI":"10.4103\/IJPC.IJPC_52_17","article-title":"Multiple nutritional deficiencies in cerebral palsy compounding physical and functional impairments","volume":"23","author":"Hariprasad","year":"2017","journal-title":"Indian J Palliat Care"},{"issue":"3","key":"10.3233\/PRM-201514_ref11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s12098-019-03084-2","article-title":"Nutritional status of indian children with cerebral palsy: A cross-sectional study","volume":"87","author":"Goyal","year":"2020","journal-title":"Indian J Pediatr"},{"issue":"5","key":"10.3233\/PRM-201514_ref12","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3923\/pjbs.2019.214.219","article-title":"Impact of iron deficiency anemia on functional abilities and muscle strength in children with spastic cerebral palsy","volume":"22","author":"El Shemy","year":"2019","journal-title":"Pak J Biol Sci"},{"key":"10.3233\/PRM-201514_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2018.11.002"},{"issue":"5","key":"10.3233\/PRM-201514_ref14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s12185-008-0191-3","article-title":"Increased incidence of iron deficiency anemia secondary to inadequate iron intake in institutionalized, young patients with cerebral palsy","volume":"88","author":"Papadopoulos","year":"2008","journal-title":"Int J Hematol"},{"issue":"1","key":"10.3233\/PRM-201514_ref15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s13312-015-0571-8","article-title":"Hereditary folate malabsorption with extensive intracranial calcification","volume":"52","author":"Ahmad","year":"2015","journal-title":"Indian Pediatr"},{"issue":"3","key":"10.3233\/PRM-201514_ref16","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1159\/000488280","article-title":"Perinatal outcome and long- term neurodevelopment after intracranial haemorrhage due to fetal and neonatal alloimmune thrombocytopenia","volume":"45","author":"Winkelhorst","year":"2019","journal-title":"Fetal Diagn Ther"},{"issue":"2","key":"10.3233\/PRM-201514_ref17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s12098-014-1543-z","article-title":"Comparison of micronutrient levels in children with cerebral palsy and neurologically normal controls","volume":"82","author":"Kalra","year":"2015","journal-title":"Indian J Pediatr"},{"issue":"10","key":"10.3233\/PRM-201514_ref18","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/j.1469-8749.2009.03384.x","article-title":"Epidemiology of low bone mineral density and fractures in children with severe cerebral palsy: A systematic review","volume":"51","author":"Mergler","year":"2009","journal-title":"Dev Med Child Neurol"},{"issue":"4","key":"10.3233\/PRM-201514_ref19","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1590\/S1679-45082015AO3321","article-title":"Bone health in cerebral palsy and introduction of a novel therapy","volume":"13","author":"Scheinberg","year":"2015","journal-title":"Einstein (Sao Paulo)"},{"issue":"2","key":"10.3233\/PRM-201514_ref20","first-page":"200","article-title":"Motor impairment and skeletal mineralization in children with cerebral palsy","volume":"67","author":"Akhter","year":"2017","journal-title":"J Pak Med Assoc"},{"issue":"9","key":"10.3233\/PRM-201514_ref21","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1111\/dmcn.13196","article-title":"Informing evidence-based clinical practice guidelines for children with cerebral palsy at risk of osteoporosis: An update","volume":"58","author":"Ozel","year":"2016","journal-title":"Dev Med Child Neurol"}],"container-title":["Journal of Pediatric Rehabilitation Medicine"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/PRM-201514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:39:19Z","timestamp":1777610359000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/PRM-201514"}},"subtitle":[],"editor":[{"given":"Rachel","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Deborah","family":"Gaebler-Spira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Michael","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Heakyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,4,6]]},"references-count":21,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/prm-201514","relation":{},"ISSN":["1874-5393","1875-8894"],"issn-type":[{"value":"1874-5393","type":"print"},{"value":"1875-8894","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,6]]}}}