{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:29:47Z","timestamp":1784604587085,"version":"3.55.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PRM"],"published-print":{"date-parts":[[2023,4,6]]},"abstract":"<jats:p>PURPOSE: This pooled analysis of data from three Phase 3 studies investigated the effects of incobotulinumtoxinA on spasticity-related pain (SRP) in children\/adolescents with uni-\/bilateral cerebral palsy (CP). METHODS: Children\/adolescents (ambulant and non-ambulant) were evaluated for SRP on increasingly difficult activities\/tasks 4 weeks after each of four incobotulinumtoxinA injection cycles (ICs) using the Questionnaire on Pain caused by Spasticity (QPS; six modules specific to lower limb [LL] or upper limb [UL] spasticity and respondent type [child\/adolescent, interviewer, or parent\/caregiver]). IncobotulinumtoxinA doses were personalized, with all doses pooled for analysis. RESULTS: QPS key item responses were available from 331 and 155 children\/adolescents with LL- and UL-spasticity, respectively, and 841\/444 (LL\/UL) of their parents\/caregivers. IncobotulinumtoxinA efficacy was evident with the first IC. Efficacy was sustained and became more robust with further subsequent ICs. By Week 4 of the last (i.e. fourth) IC, 33.8\u201353.3% of children\/adolescents reported complete SRP relief from their baseline pain for respective QPS items. Children\/adolescents reported reductions in mean LL SRP intensity at levels that surpassed clinically meaningful thresholds. Similarly, parents\/caregivers observed complete SRP relief and less frequent SRP with incobotulinumtoxinA. Similar results were found for UL SRP. CONCLUSION: These findings indicate that incobotulinumtoxinA could bring considerable benefit to children\/adolescents with spasticity by reducing SRP, even during strenuous activities.<\/jats:p>","DOI":"10.3233\/prm-220020","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T12:08:26Z","timestamp":1661861306000},"page":"83-98","source":"Crossref","is-referenced-by-count":4,"title":["Spasticity-related pain in children\/adolescents with cerebral palsy. 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