{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:50:42Z","timestamp":1777888242844,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PRM"],"published-print":{"date-parts":[[2023,12,26]]},"abstract":"<jats:p>PURPOSE: This study aimed to describe outcomes of motor function with a special focus on ambulation ability at 36 months among children with open prenatal repair of spina bifida aperta (SB). METHODS: A prospective cohort study was conducted including 87 patients with open prenatal repair of SB at the investigating center born between 2010 and 2018. Anatomic lesion level and motor function level in the neonatal period, as well as motor function level, ambulation status, and use of orthotics and assistive devices at 36 months were assessed. RESULTS: At 36 months, ambulation was assessed in 86 children; of those, 86% (n\u200a=\u200a74) were ambulating. Independent of ambulation, orthotics were worn in 81.6% (71\/87) and assistive devices in 47.1% (41\/87). Children with a lower lumbar or sacral motor function level were the first to reach independent ambulation and were more likely to ambulate at 36 months than children with higher motor function levels (p\u200a=\u200a&lt;\u200a.001). The anatomic lesion level determined on the neonatal MRI correlated with ambulation status at 36 months (p\u200a=\u200a&lt;\u200a0.001). CONCLUSION: At 36 months, most children with open prenatal repair for SB showed favourable ambulation status. However, most still used assistive devices or orthotics. Anatomic lesion level on neonatal MRI, motor function level during the neonatal period, and motor function level at 36 months were associated with ambulation status at 36 months.<\/jats:p>","DOI":"10.3233\/prm-220096","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T12:06:45Z","timestamp":1703851605000},"page":"595-604","source":"Crossref","is-referenced-by-count":4,"title":["Motor function outcomes in children with open prenatal repair of Spina Bifida Aperta at 36-month follow-up: The Zurich cohort"],"prefix":"10.1177","volume":"16","author":[{"given":"Brittany","family":"Brun","sequence":"first","affiliation":[{"name":"Child Development Center, University Children\u2019s Hospital Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Spina Bifida Study Group Zurich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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