{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:50:52Z","timestamp":1777888252209,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PRM"],"published-print":{"date-parts":[[2023,12,26]]},"abstract":"<jats:p>PURPOSE: Mothers who have had a pregnancy affected by spina bifida are advised to take 4-5\u200amg\/day folic acid pills to prevent recurrence. The folic acid prescription pattern was examined for high-risk mothers whose children received spina bifida surgery in an urban Ethiopian hospital. METHODS: Data were analyzed from a large Ethiopian urban tertiary care hospital that provided spina bifida care. General practitioners recorded 5\u200amg\/day folic acid prescriptions administered to mothers of infants with spina bifida born between January 2019 and June 2022. RESULTS: Among 500 baby-mother pairs, 340 (68%) received a 120-day prescription for 5\u200amg\/day folic acid pills. Of these 340 mothers, 331 (97%) received their folic acid prescription at their child\u2019s first or second patient encounter. Almost all mothers (94%) had documentation of only one prescription for the study duration. The percentage of mothers receiving at least one prescription varied by the baby\u2019s year of birth (2019:75%; 2020:92%; 2021:46%; Jan 2022 \u2013June 2022:79%). CONCLUSION: This prioritization of spina bifida recurrence prevention demonstrates feasibility for other healthcare centers in low-income countries. Sustained funds to provide women with free folic acid pills can favor high compliance and uptake of this prevention intervention.<\/jats:p>","DOI":"10.3233\/prm-230046","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T11:19:56Z","timestamp":1702639196000},"page":"623-628","source":"Crossref","is-referenced-by-count":2,"title":["Folic acid prescription practice for high-risk prevention of spina bifida at a tertiary care hospital in Addis Ababa, Ethiopia"],"prefix":"10.1177","volume":"16","author":[{"given":"Bethelehem","family":"Yesehak","sequence":"first","affiliation":[{"name":"Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Dorsey","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kibruyisfaw","family":"Zewdie","sequence":"additional","affiliation":[{"name":"Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya","family":"Kancherla","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yordanos","family":"Ashagre","sequence":"additional","affiliation":[{"name":"Zewditu Memorial Hospital, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"20","key":"10.3233\/PRM-230046_ref1","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1056\/nejm199911113412006","article-title":"Neural-tube defects","volume":"341","author":"Botto","year":"1999","journal-title":"N Engl J Med"},{"issue":"1","key":"10.3233\/PRM-230046_ref2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/ajpa.1330620106","article-title":"Epidemiology and genetics of neural tube defects: An application of the Utah genealogical data base","volume":"62","author":"Jorde","year":"1983","journal-title":"Am J Phys Anthropol"},{"issue":"3","key":"10.3233\/PRM-230046_ref3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/ajmg.1320050314","article-title":"The recurrence risk for neural tube defects in the United States: A collaborative study: Recurrence Risk for NTD in the United States","volume":"5","author":"Cowchock","year":"1980","journal-title":"Am J Med Genet"},{"issue":"6","key":"10.3233\/PRM-230046_ref4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1136\/jmg.21.6.413","article-title":"Recurrence risk after neural tube defects in a genetic counselling clinic","volume":"21","author":"Czeizel","year":"1984","journal-title":"J Med Genet"},{"issue":"8760","key":"10.3233\/PRM-230046_ref5","first-page":"131","article-title":"MRC Vitamin Study Research Grou","volume":"338","author":"Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study","year":"1991","journal-title":"Lancet"},{"issue":"6","key":"10.3233\/PRM-230046_ref6","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/s1701-2163(15)30230-9","article-title":"Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital anomalies","volume":"37","author":"Wilson","year":"2015","journal-title":"J Obstet Gynaecol Can"},{"issue":"5","key":"10.3233\/PRM-230046_ref8","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1136\/jmg.26.5.326","article-title":"Neural tube defect recurrence after \u201cpartial\u201d vitamin supplementation","volume":"26","author":"Sheppard","year":"1989","journal-title":"J Med Genet"},{"issue":"4","key":"10.3233\/PRM-230046_ref9","first-page":"315","article-title":"National programme for prevention of the recurrence of neural tubedefects","volume":"20","author":"Czeizel","year":"1979","journal-title":"Acta Paediatr Acad Sci Hung"},{"issue":"11","key":"10.3233\/PRM-230046_ref10","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1002\/bdra.23576","article-title":"Using state and provincial surveillance programs to reduce risk of recurrence of neural tube defects in the United States and Canada: A missed opportunity? 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