{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:54:53Z","timestamp":1777888493355,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Purpose: To investigate the effects of the androgen testosterone propionate (TP), on regeneration of the recurrent laryngeal nerve (RLN) after unilateral crush injury using assessment of vocal fold mobility (VFM) as a measure of behavioral recovery. Methods: 48 adult male rats underwent standardized crush injury of left RLN and received treatment in the form of 2 silastic capsules containing TP or controls receiving a blank capsule (untreated). Direct laryngoscopic assessment of vocal cord mobility was performed before, immediately following and 1, 2, 3, 4, 5 or 6 weeks post injury. Results: Treatment with TP enhanced the recovery of full VFM following crush injury of the RLN compared to controls. There was statistically significant improvement in VFM seen at the 1 and 2 week time points (p &lt; 0.05). By 4 weeks TP-treated rats displayed a 100% recovery of VFM function, compared to only 50% by the control group. Conclusions: TP enhances RLN functional recovery following a crush injury, which further supports its potential general applicability as a therapeutic agent in peripheral nerve injury.<\/jats:p>","DOI":"10.3233\/rnn-120287","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T18:07:07Z","timestamp":1575396427000},"page":"169-176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Androgen treatment and recovery of function following recurrent laryngeal nerve injury in the rat"],"prefix":"10.1177","volume":"31","author":[{"given":"Todd J.","family":"Brown","sequence":"first","affiliation":[{"name":"R & D Services Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA"},{"name":"Department of Anatomy & Cell Biology, Indiana School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Pittman","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology \u2013 Head & Neck Surgery, Loyola University Medical Center, Proviso, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina N.","family":"Monaco","sequence":"additional","affiliation":[{"name":"Cell Biology, Neurobiology, and Anatomy Program Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent J.","family":"Benscoter","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology \u2013 Head & Neck Surgery, Loyola University Medical Center, Proviso, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash V.","family":"Mantravadi","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology \u2013 Head & Neck Surgery, Loyola University Medical Center, Proviso, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee M.","family":"Akst","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn J.","family":"Jones","sequence":"additional","affiliation":[{"name":"R & D Services Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA"},{"name":"Department of Anatomy & Cell Biology, Indiana School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen M.","family":"Foecking","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology \u2013 Head & Neck Surgery, Loyola University Medical Center, Proviso, IL, USA"},{"name":"R and D Services Edward Hines Jr. VA Hospital, Hines, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,1]]},"container-title":["Restorative Neurology and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-120287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-120287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:45:10Z","timestamp":1777610710000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/RNN-120287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.3233\/RNN-120287"],"URL":"https:\/\/doi.org\/10.3233\/rnn-120287","relation":{},"ISSN":["0922-6028","1878-3627"],"issn-type":[{"value":"0922-6028","type":"print"},{"value":"1878-3627","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,1]]}}}