{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:53:49Z","timestamp":1780106029705,"version":"3.54.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Purpose: Induced pluripotent stem cells (iPSCs) improve behavior and form neurons after implantation into the stroke-injured adult rodent brain. How the aged brain responds to grafted iPSCs is unknown. We determined survival and differentiation of grafted human fibroblast-derived iPSCs and their ability to improve recovery in aged rats after stroke. Methods: Twenty-four months old rats were subjected to 30 min distal middle cerebral artery occlusion causing neocortical damage. After 48 h, animals were transplanted intracortically with human iPSC-derived long-term neuroepithelial-like stem (hiPSC-lt-NES) cells. Controls were subjected to stroke and were vehicle-injected. Results: Cell-grafted animals performed better than vehicle-injected recipients in cylinder test at 4 and 7 weeks. At 8 weeks, cell proliferation was low (0.7 %) and number of hiPSC-lt-NES cells corresponded to 49.2% of that of implanted cells. Transplanted cells expressed markers of neuroblasts and mature and GABAergic neurons. Cell-grafted rats exhibited less activated microglia\/macrophages in injured cortex and neuronal loss was mitigated. Conclusions: Our study provides the first evidence that grafted human iPSCs survive, differentiate to neurons and ameliorate functional deficits in stroke-injured aged brain.<\/jats:p>","DOI":"10.3233\/rnn-140404","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T18:12:24Z","timestamp":1575396744000},"page":"547-558","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Human induced pluripotent stem cells improve recovery in stroke-injured aged rats"],"prefix":"10.1177","volume":"32","author":[{"given":"Jemal","family":"Tatarishvili","sequence":"first","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Oki","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Monni","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Koch","sequence":"additional","affiliation":[{"name":"Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn and Hertie Fundation, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Memanishvili","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden"},{"name":"I. Javakhishvili Tbilisi State University, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"Buga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Molecular Psychiatry, Rostock University Medical School, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Verma","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurel","family":"Popa-Wagner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Molecular Psychiatry, Rostock University Medical School, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Br\u00fcstle","sequence":"additional","affiliation":[{"name":"Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn and Hertie Fundation, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Lindvall","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaal","family":"Kokaia","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"container-title":["Restorative Neurology and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-140404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-140404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:45:58Z","timestamp":1777610758000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/RNN-140404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.3233\/RNN-140404"],"URL":"https:\/\/doi.org\/10.3233\/rnn-140404","relation":{"is-cited-by":[{"id-type":"doi","id":"10.3389\/fnins.2019.01194","asserted-by":"object"},{"id-type":"doi","id":"10.1155\/2015\/839638","asserted-by":"object"},{"id-type":"doi","id":"10.3389\/fnins.2019.00684","asserted-by":"object"},{"id-type":"doi","id":"10.1155\/2019\/3290894","asserted-by":"object"},{"id-type":"doi","id":"10.1007\/978-981-10-2929-5_12","asserted-by":"object"},{"id-type":"doi","id":"10.3389\/fneur.2018.00634","asserted-by":"object"},{"id-type":"doi","id":"10.3389\/fneur.2019.01074","asserted-by":"object"}]},"ISSN":["0922-6028","1878-3627"],"issn-type":[{"value":"0922-6028","type":"print"},{"value":"1878-3627","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}