{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:54:26Z","timestamp":1777888466045,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,1,30]],"date-time":"2016-01-30T00:00:00Z","timestamp":1454112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2016,3,21]]},"abstract":"<jats:p>Purpose: Approximately one-fourth of stroke survivors are aphasic. Speech therapy is the main treatment approach but leaves most patients with chronic disability. Attempts to improve this situation are hampered by a lack of mechanistic understanding of the disability and treatments, reflecting the neglect of this impairment modality in pre-clinical research. Accordingly, we devised a novel murine model of speech-related impairment after stroke to investigate the role of language- and plasticity-associated molecules. Rodents communicate socially with ultrasonic vocalizations (USVs), conveying semantic and semiotic information with complex frequency modulated \u201csongs\u201d and alarm calls.<\/jats:p>\n                  <jats:p>Methods: Transient focal cerebral ischemia was induced in male C57BL6 mice via either 30 or 45 minutes of reversible right MCAO using the intraluminal filament technique. Nine days post-operatively brains are stained with TTC and analyzed for infarct volume. For behavioral measures health scores are taken (days 1\u20134), cylinder tests and USV recordings performed at days 3 and 7 post operatively. Real time PCR was performed at 24 and 48 hour and 7 day time points to quantify mRNA expression of communication-related genes ( Foxp2, Foxp1, Srpx2, Cntnap2 and Gapdh). Immunohistochemistry was performed to localize FOXP2 protein.<\/jats:p>\n                  <jats:p>Results: After middle cerebral artery occlusion of either 30 or 45 minutes duration, mice demonstrate profoundly impaired socially evoked USVs. In addition, there is suppression of the language-associated transcription factor, Forkhead box protein 2 ( Foxp2), and its downstream binding partner, contactin-associated protein 2 ( Cntnap2).<\/jats:p>\n                  <jats:p>Conclusion: These findings set a foundation for further studies of mechanisms and novel treatment strategies for post-stroke vocalization impairments.<\/jats:p>","DOI":"10.3233\/rnn-150583","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T11:26:02Z","timestamp":1458645962000},"page":"287-295","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrasonic vocalization in murine experimental stroke: A mechanistic model of aphasia"],"prefix":"10.1177","volume":"34","author":[{"given":"Julie","family":"Palmateer","sequence":"first","affiliation":[{"name":"Departments of Neuroscience, University of Texas at Austin, Austin, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[{"name":"Departments of Neuroscience, University of Texas at Austin, Austin, TX, USA"},{"name":"Nanjing University Medical School, Nanjing, PR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arushi","family":"Pandya","sequence":"additional","affiliation":[{"name":"Departments of Psychology, University of Texas at Austin, Austin, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianna","family":"Martin","sequence":"additional","affiliation":[{"name":"Departments of Psychology, University of Texas at Austin, Austin, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungita","family":"Kumar","sequence":"additional","affiliation":[{"name":"Departments of Psychology, University of Texas at Austin, Austin, TX, 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