{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:54:27Z","timestamp":1777888467809,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2017,6,8]]},"abstract":"<jats:p>Background: Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke.<\/jats:p>\n                  <jats:p>Objective: To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion.<\/jats:p>\n                  <jats:p>Methods: 22 Sprague-Dawley male rats weighing 275\u2013300\u200ag were randomized into three groups by block randomization. In the sham group ( n\u200a=\u200a7), the neck was opened, but neither MCA was occluded, nor any drug was administered.<\/jats:p>\n                  <jats:p>The control group ( n\u200a=\u200a7) was treated with vehicle (methocel) by gavage for 14 days after MCA occlusion. In the DMF-treated group ( n\u200a=\u200a8), treatment was performed with 15\u200amg\/kg body weight dimethyl fumarate twice a day for 14 days after MCA occlusion. Transient occlusion of the right MCA was performed by intraluminal thread method in the DMF-treated and the control group. Neurological deficit score (NDS), pole test, and adhesive removal test were performed before the surgery, and on post-operative Days 0, 3, 5, 7, 10, and 14. After the final behaviour test, the animals\u2019 brains were perfused and removed. Brains were frozen and sectioned serially and coronally using a cryostat. Infract volume and brain volume were estimated by stereology.<\/jats:p>\n                  <jats:p>Results: The percentage of infarct volume was significantly lower in DMF-treated animals (5.76%) than in the control group (22.39%) ( P\u200a&lt;\u200a0.0001). Regarding behavioural tests, the DMF-treated group showed better function in NDS on Days 7 ( P\u200a=\u200a0.041) and 10 ( P\u200a=\u200a0.046), but not in pole and adhesive removal tests. There was no significant correlation between behavioural tests and histological results.<\/jats:p>\n                  <jats:p>Conclusion: Dimethyl fumarate could be beneficial as a potential neuroprotective agent in the treatment of stroke.<\/jats:p>","DOI":"10.3233\/rnn-160670","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T13:04:01Z","timestamp":1494335041000},"page":"265-274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic effects of oral dimethyl fumarate on stroke induced by middle cerebral artery occlusion: An animal experimental study"],"prefix":"10.1177","volume":"35","author":[{"given":"Anahid","family":"Safari","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Department of Pharmacology, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Fazeli","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Shiraz University, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Namavar","sequence":"additional","affiliation":[{"name":"Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Histomorphometry and stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Departmentof Anatomy, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Tanideh","sequence":"additional","affiliation":[{"name":"Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyman","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshin","family":"Borhani-Haghighi","sequence":"additional","affiliation":[{"name":"Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"issue":"51","key":"ref001","first-page":"2879","author":"Ansari S.","year":"2011","journal-title":"Journal of Visualized 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