{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:55:11Z","timestamp":1777888511366,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2018,7,22]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The central nervous system involvement, in terms of a maladaptive sensory-motor plasticity, is well known in patients with dystrophic myotonias (DMs). To date, there are no data suggesting a central nervous system involvement in non-dystrophic myotonias (NDMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate sensory-motor plasticity in patients with Myotonia Congenita (MC) and Paramyotonia Congenita (PMC) with or without mexiletine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twelve patients with a clinical, genetic, and electromyographic evidence of MC, fifteen with PMC, and 25 healthy controls (HC) were included in the study. TMS on both primary motor cortices (M1) and a rapid paired associative stimulation (rPAS) paradigm were carried out to assess M1 excitability and sensory-motor plasticity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>patients showed a higher cortical excitability and a deterioration of the topographic specificity of rPAS aftereffects, as compared to HCs. There was no correlation among neurophysiological and clinical-demographic characteristics. Noteworthy, the patients who were under mexiletine showed a minor impairment of the topographic specificity of rPAS aftereffects as compared to those who did not take the drug.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>our findings could suggest the deterioration of cortical sensory-motor plasticity in patients with NDMs as a trait of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/rnn-170796","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T11:15:29Z","timestamp":1528456529000},"page":"459-467","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the muscular involvement in non-dystrophic myotonias: The emerging role of neuromodulation"],"prefix":"10.1177","volume":"36","author":[{"given":"Simona","family":"Portaro","sequence":"first","affiliation":[{"name":"IRCSS Centro Neurolesi Bonino Pulejo, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Naro","sequence":"additional","affiliation":[{"name":"IRCSS Centro Neurolesi Bonino Pulejo, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Bramanti","sequence":"additional","affiliation":[{"name":"Institute of Applied Sciences and Intelligent Systems \u201cEdoardo Caianello\u201d (ISASI), National Research Council of Italy, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Leo","sequence":"additional","affiliation":[{"name":"IRCSS Centro Neurolesi Bonino Pulejo, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Manuli","sequence":"additional","affiliation":[{"name":"IRCSS Centro Neurolesi Bonino Pulejo, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Balletta","sequence":"additional","affiliation":[{"name":"IRCSS Centro Neurolesi Bonino Pulejo, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Trinchera","sequence":"additional","affiliation":[{"name":"IRCSS Centro Neurolesi Bonino Pulejo, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Placido","family":"Bramanti","sequence":"additional","affiliation":[{"name":"IRCSS Centro Neurolesi Bonino Pulejo, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco Salvatore","family":"Calabr\u00f2","sequence":"additional","affiliation":[{"name":"IRCSS Centro Neurolesi Bonino Pulejo, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)81020-M"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.5.524"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2610-6"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2015.01.006"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(96)81859-5"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6462-1"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00823"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(87)90011-3"},{"key":"ref009","unstructured":"CatterallW.A, & MackieK. (2001) Local anesthetics, In: HardmanJ.G., LimbirdL.E., MolinoffmB., RuddonR.W., GilmanA.G.(Eds.), Goodman and Gilman\u2019s the Pharmacological Basis ofTherapeutics (pp. 367\u2013384). New York: Macmillan Publishing Co."},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199204000-00005"},{"key":"ref011","first-page":"268","volume":"57","author":"De Luca A","year":"2000","journal-title":"MolecularPharmacology"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005118"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.04.006"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)36782-5"},{"key":"ref015","first-page":"596","volume":"344","author":"De Luca A","year":"1991","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.10.1849"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018479"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.243485"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.08.001"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1986.tb03442.x"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(92)90108-I"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23683"},{"key":"ref025","first-page":"497","volume":"69","author":"Hille B.","year":"1977","journal-title":"The Journal of GeneralPhysiology"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170710"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.11.1347"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1317"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-61343-9_9"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050296"},{"key":"ref031","volume-title":"Molecular Cell Biology","author":"Lodish H","year":"2000","edition":"4"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dc1a3a"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dc1a3a"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.9.1441"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00563-4"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp294"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.3233\/JND-150088"},{"key":"ref038","first-page":"795","volume":"75","author":"Walsh V.","year":"2004","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1610"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200504000-00007"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-980X(97)00023-4"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2003.12.025"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.3.1037"},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-015-8356-8"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828cf8d0"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178470"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.114025"},{"key":"ref048","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-980X(97)00041-6"},{"key":"ref049","first-page":"933","volume-title":"Goodman and Gilman\u2019s the Pharmacological Basis of Therapeutics","author":"Roden D.M.","year":"2001"},{"key":"ref050","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(94)90029-9"},{"key":"ref051","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000414"},{"key":"ref052","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.12.3381"},{"key":"ref053","first-page":"e49","volume":"81","author":"Shen Y","year":"2017","journal-title":"BiologicalPsychiatry"},{"key":"ref054","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.02.006"},{"key":"ref055","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199809)21:9<1209::AID-MUS15>3.0.CO;2-M"},{"key":"ref056","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.12607"},{"key":"ref057","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023317"},{"key":"ref058","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00430-0"},{"key":"ref059","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01616.x"},{"key":"ref060","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13790.x"},{"key":"ref061","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0010-z"},{"key":"ref062","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)89060-4"},{"key":"ref063","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.054973"},{"key":"ref064","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0591t.x"}],"container-title":["Restorative Neurology and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-170796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/RNN-170796","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-170796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:47:54Z","timestamp":1777610874000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/RNN-170796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,6]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7,22]]}},"alternative-id":["10.3233\/RNN-170796"],"URL":"https:\/\/doi.org\/10.3233\/rnn-170796","relation":{},"ISSN":["0922-6028","1878-3627"],"issn-type":[{"value":"0922-6028","type":"print"},{"value":"1878-3627","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,6]]}}}