{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:56:21Z","timestamp":1777888581051,"version":"3.51.4"},"reference-count":105,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2020,8,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess whether treatment with the Limoli Retinal Restoration Technique (LRRT) can be performed in patients with retinitis pigmentosa (RP), grafting the autologous cells in a deep scleral pocket above the choroid of each eye to exert their beneficial effect on the residual retinal cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The patients were subjected to a complete ophthalmological examination, including best corrected visual acuity (BCVA), close-up visus measurements, spectral domain-optical coherence tomography (SD-OCT), microperimetry (MY), and electroretinography (ERG). Furthermore, the complete ophthalmological examination was carried out at baseline (T0) and at 6 months (T180) after surgery. The Shapiro\u2013Wilk test was used to assess the normality of distribution of the investigated parameters. A mixed linear regression model was used to analyse the difference in all the studied parameters at T0 and T180, and to compare the mean change between the two groups. All statistical analyses were performed with STATA 14.0 (Collage Station, Texas, USA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>LRRT treatment was performed in 34 eyes of 25 RP patients recruited for the study. The eyes were classified in two groups on the basis of foveal thickness (FT) assessed by SD-OCT: 14 eyes in Group A (FT\u2264190 \u03bcm) and the remaining 20 ones in Group B (FT\u200a&gt;\u200a190 \u03bcm). Although it had not reached the statistical significance, Group B showed a better improvement in BCVA, residual close-up visus and sensitivity than Group A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Previous studies have described the role of LRRT in slowing down retinal degenerative diseases. Consequently, this surgical procedure could improve the clinical and rehabilitative prognostic parameters in RP patients. On the other hand, further clinical research and studies with longer follow-up will be needed to evaluate its efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/rnn-190970","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T12:24:05Z","timestamp":1587126245000},"page":"223-237","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Mesenchymal stem cell surgery, rescue and regeneration in retinitis pigmentosa: clinical and rehabilitative prognostic aspects"],"prefix":"10.1177","volume":"38","author":[{"given":"Paolo Giuseppe","family":"Limoli","sequence":"first","affiliation":[{"name":"Low Vision Research Centre of Milan, p.zza Sempione 3, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celeste Silvana Serena","family":"Limoli","sequence":"additional","affiliation":[{"name":"Low Vision Research Centre of Milan, p.zza Sempione 3, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Ulises","family":"Morales","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurosciences, University of Nottingham, Queen\u2019s Medical Centre, Nottingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo Maria","family":"Vingolo","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, p.le A. 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