{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:22:47Z","timestamp":1791246167090,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Purpose: Little is known about neuronal changes during ageing in the visual system of mice which are increasingly being used as animal models for human visual disorders. Methods and results: Measuring the optomotor response to moving gratings, visual acuity of C57BL\/6-mice was 0.39 cycles\/degree (cyc\/deg) until 12 months of age and declined to 0.27 cyc\/deg (by 30%) at 26 months. In the visual water task, a cortex-dependent task based on visual discrimination learning, visual acuity remained stable at 0.58 cyc\/deg up to 21 months and then declined to 0.48 cyc\/deg (by 19%) at 27 months. Visual cortical activity recorded by optical imaging declined by 33% between seven and 23 months of age. After monocular deprivation and daily testing of the optomotor response, visual acuity of the open eye increased by 29% in 4 to 7-month-old animals, while the increase was only 13% in 23-month-old mice. Interestingly, interindividual variability generally increased with age, so that some 23-month-old mice retained visual acuity and interocular plasticity like 4 or 7-month-old animals. Conclusions: In summary, reduced visual function was accompanied by a reduction of both visual cortical responses and interocular plasticity indicating a central nervous system component in age-related vision loss in mice.<\/jats:p>","DOI":"10.3233\/rnn-2012-110192","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T18:05:49Z","timestamp":1575396349000},"page":"161-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Vision and visual plasticity in ageing mice"],"prefix":"10.1177","volume":"30","author":[{"given":"Konrad","family":"Lehmann","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Allgemeine Zoologie und Tierphysiologie, Friedrich-Schiller-Universit\u00e4t Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Friedrich","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Allgemeine Zoologie und Tierphysiologie, Friedrich-Schiller-Universit\u00e4t Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegrid","family":"L\u00f6wel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Allgemeine Zoologie und Tierphysiologie, Friedrich-Schiller-Universit\u00e4t Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"container-title":["Restorative Neurology and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-2012-110192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-2012-110192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:57:40Z","timestamp":1777611460000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/RNN-2012-110192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.3233\/RNN-2012-110192"],"URL":"https:\/\/doi.org\/10.3233\/rnn-2012-110192","relation":{"is-cited-by":[{"id-type":"doi","id":"10.3389\/fnbeh.2016.00042","asserted-by":"object"},{"id-type":"doi","id":"10.1155\/2012\/892784","asserted-by":"object"},{"id-type":"doi","id":"10.1007\/s00429-016-1232-y","asserted-by":"object"}]},"ISSN":["0922-6028","1878-3627"],"issn-type":[{"value":"0922-6028","type":"print"},{"value":"1878-3627","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,1]]}}}