{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:59:45Z","timestamp":1777888785044,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Restorative Neurology and Neuroscience"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    Purpose: To compare neuroprotection and therapeutic time windows of two diazepam regimens on retinal ganglion cells (RGCs) after rat optic nerve transection (ONT). Methods: Adult rats received initial intraperitoneal diazepam injections 30 minutes before left ONT, followed by daily diazepam (Regimen-A) or every 8 hours for 3 days (Regimen-B) until they were killed at Day 7 or 14. Initial diazepam in Regimen-A and Regimen-B was delayed to 3, 6, 7, 9, 10, 12 and 6, 7, 8, 9, 10, 12 hours after ONT and these animals survived for 7 days. The effect of daily combinational uses of diazepam and bicuculline was assayed at 7 days. Results: Regimen-A induced higher RGC densities than those in control and Regimen-B groups at Day 7, but lower density than Regimen-B did at Day 14. When initial diazepam was delayed beyond 6 or 8 hours after ONT with Regimen-A and Regimen-B, the promoting effects of diazepam on RGC densities disappeared. Bicuculline completely inhibited the protection of diazepam. Conclusions: Prolonged neuroprotection on RGCs at Day 14 and extended therapeutic time window for 8 hours can be achieved by Regimen-B, while Regimen-A induces a stronger neuroprotection at Day 7. Diazepam neuroprotection is mediated through GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor.\n                  <\/jats:p>","DOI":"10.3233\/rnn-2012-110216","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T18:06:19Z","timestamp":1575396379000},"page":"335-343","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Different neuroprotection and therapeutic time windows by two specific diazepam regimens on retinal ganglion cells after optic nerve transection in adult rats"],"prefix":"10.1177","volume":"30","author":[{"given":"Ling","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Hong","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Paediatrics at Xijing Hospital, The Fourth Military Medical University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Dong","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Mei","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-An","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-Ying","family":"Jiao","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Wei","family":"You","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong","family":"Ju","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"container-title":["Restorative Neurology and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-2012-110216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/RNN-2012-110216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:57:47Z","timestamp":1777611467000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/RNN-2012-110216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.3233\/RNN-2012-110216"],"URL":"https:\/\/doi.org\/10.3233\/rnn-2012-110216","relation":{},"ISSN":["0922-6028","1878-3627"],"issn-type":[{"value":"0922-6028","type":"print"},{"value":"1878-3627","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,1]]}}}