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Animals were assigned to one of three experimental cohorts: control, stroke, stroke\u200a+\u200aHSC. One, three and five weeks following a unilateral stroke all animals were tested on motor skills after which intracortical microstimulation was used to derive maps of forelimb movement representations within the motor cortex ipsilateral to the ischemic injury. Results: Stroke\u200a+\u200aHSC animals significantly outperformed stroke animals on single pellet reaching at weeks 3 and 5 (28\u00b13% and 33\u00b13% versus 11\u00b14% and 17\u00b13%, respectively, p\u200a&lt;\u200a0.05 at both time points). Control animals scored 44\u00b11% and 47\u00b11%, respectively. Sunflower seed opening task was significantly improved in the stroke\u200a+\u200aHSC cohort versus the stroke cohort at week five-post stroke (79\u00b14 and 48\u00b15, respectively, p\u200a&lt;\u200a0.05). Furthermore, Stroke\u200a+\u200aHSC animals had significantly larger forelimb motor maps than animals in the stroke cohort. Overall infarct size did not significantly differ between the two stroked cohorts. Conclusion: These data suggest that post stroke treatment of HSC enhances the functional integrity of residual cortical tissue, which in turn supports improved behavioral outcome, despite no observed reduction in infarct size.<\/jats:p>","DOI":"10.3233\/rnn-231378","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T14:17:15Z","timestamp":1716905835000},"page":"139-149","source":"Crossref","is-referenced-by-count":0,"title":["Hematopoietic Endothelial Progenitor cells enhance motor function and cortical motor map integrity following cerebral ischemia"],"prefix":"10.1177","volume":"42","author":[{"given":"Aqeela","family":"Afzal","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagheme","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuha","family":"Warraich","sequence":"additional","affiliation":[{"name":"San Bio, Inc. 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