{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:01:43Z","timestamp":1783191703096,"version":"3.54.6"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643684321","type":"print"},{"value":"9781643684338","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,23]]},"abstract":"<jats:p>This experiment aimed to investigate the protective effect of sea buckthorn (Hipphophae rhamnoides) extract on an animal model of NAFLD induced by high-fat and cholesterol diet. Twenty-five SPF-grade male KM mice were randomly divided into the blank control group, high-fat model group, sea-buckthorn low-dose group, sea-buckthorn medium-dose group, and sea-buckthorn high-dose group. During the whole experiment, the high-fat model group and sea-buckthorn treatment group were fed high-fat and high-cholesterol diet to build the fatty liver model, whereas the blank control group was fed ordinary diet. The high-fat model group and blank control group were intragastrically given normal saline, and each sea buckthorn treatment group was intragastrically given different concentrations of sea buckthorn extract. After 5 weeks of intervention using the abovementioned method, the experiment was completed; relevant serological indexes were determined, and the liver coefficient was calculated. Our results demonstrated that the liver coefficient in the high-dose sea buckthorn group was extremely significantly decreased (P &lt; 0.01) compared with that in the high-fat model group. In addition, the concentration of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in serum of mice was decreased by the intervention of sea buckthorn extract, whereas the concentration of high-density lipoprotein cholesterol (HDL-C) was increased. Significant differences were observed between the sea-buckthorn high-dose treatment group and the high-fat model group (P &lt; 0.05). The extracts of sea buckthorn had a certain protective effect on non-alcoholic fatty liver. This study lays an important foundation in developing and using sea buckthorn extract as a clinical drug and guiding people to take health care products reasonably.<\/jats:p>","DOI":"10.3233\/shti230891","type":"book-chapter","created":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T13:55:15Z","timestamp":1701006915000},"source":"Crossref","is-referenced-by-count":3,"title":["Protective Effect of Sea Buckthorn (Hipphophae Rhamnoides) Extract on Liver Injury Induced by High-Fat Diet in Mice"],"prefix":"10.3233","author":[{"given":"Si","family":"Sun","sequence":"first","affiliation":[{"name":"College of Basic Medicine, Changsha Medical University, Changsha, Hunan 410219, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Changsha Medical University, Changsha, Hunan 410219, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Changsha Medical University, Changsha, Hunan 410219, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"He","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Changsha Medical University, Changsha, Hunan 410219, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Advances in Biomedical and Bioinformatics Engineering"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI230891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T13:55:17Z","timestamp":1701006917000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI230891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"ISBN":["9781643684321","9781643684338"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti230891","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]}}}