{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:45:11Z","timestamp":1772034311954,"version":"3.50.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643684321","type":"print"},{"value":"9781643684338","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,23]]},"abstract":"<jats:p>Objective: To study the effect and mechanism of electroacupuncture at \u201cBaihui, Yintang and Shuigou\u201d acupoints on learning and memory in Post-Stroke Cognitive Impairment (PSCI) mice. Methods: 52 male C57BL\/6 mice were used to establish a MACO model by using middle cerebral artery occlusion (n=38), while the Sham only ligated at the distal end of the external carotid artery (n=14). After 28 days, the MCAO was divided into three groups based on the escape latency of Morris water maze: non cognitive impairment (MNP), post-stroke cognitive impairment (MP), and electroacupuncture intervention group (MPEA). In the MPEA, electroacupuncture at \u201cBaihui and Yintang\u201d acupoints was performed for 20 minutes (density wave, 2\/15HZ and 1mA) supplemented by acupuncture at \u201cShuigou\u201d acupoints once a day with a 6-day course of treatment. The intervention last for 2 courses with a 1-day interval. Morris water maze was used to detect the cognitive function of mice in each group; Nissl staining was used to observe hippocampal neurons; Western blot was used to detect the expression of GluA1, Syp, and Syt-1 in the affected hippocampus; IHC was used to detect the expression of Syp in the CA1 region of the contralateral hippocampus. Conclusion: Acupuncture at points \u201cBaihui, Yintang, and Shuigou\u201d can improve the learning and memory abilities of PSCI mice, and its mechanism is related to synaptic plasticity of hippocampus.<\/jats:p>","DOI":"10.3233\/shti230905","type":"book-chapter","created":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T13:55:34Z","timestamp":1701006934000},"source":"Crossref","is-referenced-by-count":3,"title":["Electroacupuncture at \u201cBaihui, Yintang and Shuigou\u201d Acupoints Improves Post-Stroke Cognitive Impairment in Mice"],"prefix":"10.3233","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China"},{"name":"Anyang Vocational and Technical College, Anyang 455000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuran","family":"Gui","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China"},{"name":"Institute of Cerebrovascular Disease, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changlong","family":"Leng","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China"},{"name":"Institute of Cerebrovascular Disease, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youwei","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China"},{"name":"Institute of Cerebrovascular Disease, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiji","family":"Shu","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Advances in Biomedical and Bioinformatics Engineering"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI230905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T13:55:35Z","timestamp":1701006935000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI230905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"ISBN":["9781643684321","9781643684338"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti230905","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]}}}