{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:36:45Z","timestamp":1779403005611,"version":"3.53.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686615","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"abstract":"<jats:p>We applied explainable machine learning to optical coherence tomography (OCT) data from 168 pediatric NF-1 patients to predict vision abnormalities. The Balanced Random Forest model achieved an AUC-ROC of 0.82. SHapley Additive exPlanations (SHAP) analysis identified data-driven cut-offs providing actionable clinical thresholds. Combining multiple abnormal OCT features further improved specificity. This approach demonstrates the value of interpretable AI for early risk detection and individualized care in pediatric NF-1.<\/jats:p>","DOI":"10.3233\/shti260142","type":"book-chapter","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:56:28Z","timestamp":1779400588000},"source":"Crossref","is-referenced-by-count":0,"title":["Explainable ML for Predicting Vision Loss in Pediatric NF-1 Patients Using OCT Data"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0794-3653","authenticated-orcid":false,"given":"Ayelet","family":"Goldstein","sequence":"first","affiliation":[{"name":"Jerusalem Multidisciplinary College, Computer Science Department"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Fresno","family":"Canada","sequence":"additional","affiliation":[{"name":"Universitat Polit\u00e8cnica de Catalunya, Department of Optics and Optometry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Prat","family":"Bartomeu","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u de Barcelona, Ophthalmology Department"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Salvador","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u of Barcelona, Oncology Department"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Llorca","family":"Cardenosa","sequence":"additional","affiliation":[{"name":"Hospital General de Castell\u00f3, Ophthalmology Department"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric Puigvent\u00f3s","family":"Rosanas","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u de Barcelona, Ophthalmology Department"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Gispets","family":"Parcerias","sequence":"additional","affiliation":[{"name":"Universitat Polit\u00e8cnica de Catalunya, Department of Optics and Optometry"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Opening the Personal Gate between Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI260142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:56:29Z","timestamp":1779400589000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI260142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"ISBN":["9781643686615"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti260142","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}