{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:38:00Z","timestamp":1779403080164,"version":"3.53.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686615","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"abstract":"<jats:p>Celiac Disease (CD) is an autoimmune disorder triggered by gluten ingestion in genetically susceptible individuals. Its heterogeneous presentation, especially in pediatric patients, limits the effectiveness of current symptom-based classifications such as the Oslo definitions. This study proposes a framework based on Topological Data Analysis (TDA) to identify new, clinically meaningful sub-phenotypes of pediatric CD. We used a multicentric dataset of over 3,000 children. Compared with standard clustering (DBSCAN, Agglomerative, K-Medoids), our TDA Mapper revealed stable, interpretable communities reflecting serological and clinical patterns. Results indicate that serology, histology, and comorbidities jointly define distinct pediatric phenotypes, supporting data-driven approaches for precision medicine in CD.<\/jats:p>","DOI":"10.3233\/shti260145","type":"book-chapter","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:56:33Z","timestamp":1779400593000},"source":"Crossref","is-referenced-by-count":0,"title":["Sub-Phenotyping of Pediatric Celiac Disease with Topological Data Analysis"],"prefix":"10.3233","author":[{"given":"Daniele","family":"Pala","sequence":"first","affiliation":[{"name":"Dept. of Management, Information and Production Engineering, University of Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Albi","sequence":"additional","affiliation":[{"name":"Dept. of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Brembilla","sequence":"additional","affiliation":[{"name":"Dept. of Management, Information and Production Engineering, University of Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Lenzi","sequence":"additional","affiliation":[{"name":"Dept. of Management, Information and Production Engineering, University of Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Medolago","sequence":"additional","affiliation":[{"name":"Dept. of Management, Information and Production Engineering, University of Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Sirtoli","sequence":"additional","affiliation":[{"name":"Dept. of Management, Information and Production Engineering, University of Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Dagliati","sequence":"additional","affiliation":[{"name":"Dept. of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Opening the Personal Gate between Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI260145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:56:33Z","timestamp":1779400593000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI260145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"ISBN":["9781643686615"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti260145","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}